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Vascular Endothelium : Mechanisms of Cell Signaling - John D. Catravas

Vascular Endothelium

Mechanisms of Cell Signaling

By: John D. Catravas (Editor), Allan D. Callow (Editor), Una S. Ryan (Editor)

Hardcover

Published: 1st January 1999
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This volume explores the various molecular pathways via which endothelial cells communicate among them as well as with other vascular cells (e.g., smooth muscle cells, leukocytes, platelets, fibroblasts, etc.) in order to transduce physiologic and pathologic signals. The most important pathologies discussed are: - pulmonary vascular diseases - thrombosis - hypertension (systemic and pulmonary) - inflammation - angiogenesis - cerebrovascular disease - transplantation - atherosclerosis. The largest fraction of time was devoted to the mechanisms and signals underlying these diseases.

Preface
List of Participants
Transcriptional Regulation of Vascular Endothelial Cell Proteinsp. 3
Cellular and Molecular Regulation of Type II Nitric Oxide Synthase Expression in Vascular Smooth Muscle Cellsp. 19
Allogeneic and Xenogeneic Interactions between Endothelial Cells and Human T Cells During Transplant Rejectionp. 33
Cytokine Activation of Endothelial Cells: an Old Paradigm with New Elementsp. 51
Shear Stress-Mediated Regulation of ERK1/2 in Endothelial Cells: Signal Transduction Pathwaysp. 63
Endothelial Dysfunction in Atherosclerosisp. 81
Genetic Factors in Coronary Heart Diseasep. 89
Role of Caveolae in Mechanotransductionp. 97
Endothelin and Pulmonary Hypertensionp. 117
Endothelial Nitric Oxide Synthase Regulation via Protein-Protein Interactionsp. 133
Regulation of Nitric Oxide Synthase by Subcellular Targeting Modifications and Protein-Protein Interactionsp. 149
Endothelial and Smooth Muscle Plasminogen Activators in Fibrinolysis, Cell Migration and Repair-Associated Angiogenesisp. 157
Endothelial Cell Matrix Interactionsp. 179
Endothelial Cell Control of Platelet Activation: Regulation of Synthesis and Secretion of Prostacyclin, Nitric Oxide and Von Willebrand Factorp. 185
Thrombin as an Angiogenic Factor: Pathophysiological Implicationsp. 195
Abstracts of Oral Presentationsp. 201
Abstracts of Poster Presentationsp. 243
Author Indexp. 287
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9789051994438
ISBN-10: 9051994435
Series: NATO Science Series A: Life Sciences
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 304
Published: 1st January 1999
Publisher: IOS Press
Country of Publication: US
Dimensions (cm): 23.4 x 15.6  x 1.9
Weight (kg): 0.6
Edition Number: 1