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Uses of Inorganic Chemistry in Medicine - Nicholas P. Farrell

Uses of Inorganic Chemistry in Medicine

By: Nicholas P. Farrell (Editor), J.H. McNeill (Contribution by), Katherine H. Thompson (Contribution by), Lloyd R. Kelland (Contribution by), N. Birch (Contribution by)

Hardcover Published: 27th May 1999
ISBN: 9780854044443
Number Of Pages: 172

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Metal-based drugs are a commercially important sector of the pharmaceutical business, yet most bioinorganic textbooks lack the space to cover comprehensively the subject of metals in medicine. Uses of Inorganic Chemistry in Medicine approaches an understanding of the topic in a didactic and systematic manner. The field of inorganic chemistry in medicine may usefully be divided into two main categories - drugs which target metal ions in some form, whether free or protein-bound, and secondly, metal-based drugs where the central metal ion is usually the key feature of the mechanism of action. This latter category can further be subdivided into pharmacodynamic and chemotherapeutic applications, as well as those of imaging. The book summarises the chemical and biological studies on clinically used agents of lithium, gold and platinum, as well as highlighting the research on prospective new drugs, including those based on vanadium and manganese. The coverage allows a clear distinction between pharmacodynamic and therapeutic properties of metal-based drugs and focuses not only on those clinical agents in current use, but also on new drugs and uses. This book serves to fill an important niche, bridging bioinorganic and medicinal chemistry and will undoubtedly be of use to senior undergraduates and postgraduates, as well as being an invaluable asset for teachers and researchers in the discipline.

Industry Reviews

"This hard-backed book is well-produced and well-referenced and is likely to be widely used by advanced undergraduates and graduate research students, hopefully not just chemists but biochemists and pharmacologists too." * The Alchemist - ChemWeb Website Oct 1999 * "... an attractive buy ... well-written ..." * Journal of Medicinal Chemistry, 1999, Vol 42, No 23 * "... an excellent volume for inspiring research students ..." * Applied Organometallic Chemistry, 14, 281-285, 2000 *

Overviewp. 1
Biomedical Uses of Lithiump. 11
Gold Complexes with Anti-arthritic, Anti-tumour and Anti-HIV Activityp. 26
Nitric Oxide in Physiology and Medicinep. 58
Therapeutic Aspects of Manganese(II)-based Superoxide Dismutase Mimicsp. 77
Vanadium Compounds as Possible Insulin Modifiersp. 93
Cisplatin-based Anticancer Agentsp. 109
Dinuclear and Trinuclear Platinum Anticancer Agentsp. 124
Oxidation Damage by Bleomycin, Adriamycin and Other Cytotoxic Agents That Require Iron or Copperp. 135
Subject Indexp. 158
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780854044443
ISBN-10: 0854044442
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 172
Published: 27th May 1999
Country of Publication: GB
Dimensions (cm): 24.87 x 16.08  x 1.5
Weight (kg): 0.38