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Understanding Bioinformatics : 1st edition, 2007  - Marketa J. Zvelebil

Understanding Bioinformatics

1st edition, 2007

Paperback

Published: 25th August 2007
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Suitable for advanced undergraduates and postgraduates, Understanding Bioinformatics provides a definitive guide to this vibrant and evolving discipline. The book takes a conceptual approach. It guides the reader from first principles through to an understanding of the computational techniques and the key algorithms. Understanding Bioinformatics is an invaluable companion for students from their first encounter with the subject through to more advanced studies.

The book is divided into seven parts, with the opening part introducing the basics of nucleic acids, proteins and databases. Subsequent parts are divided into 'Applications' and 'Theory' Chapters, allowing readers to focus their attention effectively. In each section, the Applications Chapter provides a fast and straightforward route to understanding the main concepts and 'getting started'. Each of these is then followed by Theory Chapters which give greater detail and present the underlying mathematics. In Part 2, Sequence Alignments, the Applications Chapter shows the reader how to get started on producing and analyzing sequence alignments, and using sequences for database searching, while the next two chapters look closely at the more advanced techniques and the mathematical algorithms involved. Part 3 covers evolutionary processes and shows how bioinformatics can be used to help build phylogenetic trees. Part 4 looks at the characteristics of whole genomes. In Parts 5 and 6 the focus turns to secondary and tertiary structure - predicting structural conformation and analysing structure-function relationships. The last part surveys methods of analyzing data from a set of genes or proteins of an organism and is rounded off with an overview of systems biology.

The writing style of Understanding Bioinformatics is notable for its clarity, while the extensive, full-color artwork has been designed to present the key concepts with simplicity and consistency. Each chapter uses mind-maps and flow diagrams to give an overview of the conceptual links within each topic.

'Congratulations on a fine book! I do not think I have seen such a comprehensive text on bioinformatics algorithms and techniques before. I think this will be an invaluable resource for the bioinformatics community and researchers of neighbouring disciplines.' - Jaap Heringa, Free University, Amsterdam 'This is very well done. Compared to other competing textbooks, your book will be probably the first one that explains gene finding in detail.' - Sun Kim, Indiana University, Bloomington, USA '...provides an outstanding introduction to the main bioinformatics problems and tools, well-balanced between applications to biological problems and theory behind data processing methods... an excellent and updated book for students of Bioinformatics' Computer Methods and Programs in Biomedicine

Background Basics
The Nucleic Acid World
Protein Structure
Dealing with Databases
Sequence Alignments
Producing and Analyzing Sequence Alignments
Pairwise Sequence Alignment and Database Searching
Patterns, Profiles, and Multiple Alignments
Evolutionary Processes
Recovering Evolutionary History
Building Phylogenetic Trees
Genome Characteristics
Revealing Genome Features
Gene Detection and Genome Annotation
Secondary Structures
Obtaining Secondary Structure from Sequence
Predicting Secondary Structures
Tertiary Structures
Modeling Protein Structure
Analyzing Structure-Function Relationships
Cells and Organisms
Proteome and Gene Expression Analysis
Clustering Methods and Statistics
Systems Biology
Appendices: Background Theory
Probability, Information, and Bayesian Analysis
Molecular Energy Functions
Function Optimization
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780815340249
ISBN-10: 0815340249
Audience: Tertiary; University or College
Format: Paperback
Language: English
Number Of Pages: 798
Published: 25th August 2007
Publisher: Taylor & Francis Inc
Country of Publication: US
Dimensions (cm): 27.3 x 21.5  x 3.7
Weight (kg): 1.612
Edition Number: 1