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Triggering of Acute Coronary Syndromes : Implications for Prevention - Stefan N. Willich

Triggering of Acute Coronary Syndromes

Implications for Prevention

By: Stefan N. Willich (Editor), James E. Muller (Editor), Eugene Braunwald (Foreword by)

Hardcover Published: 30th November 1995
ISBN: 9780792336051
Number Of Pages: 430

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Cardiovascular diseases account for about half of total mortality in industrialised societies. This figure has declined only slightly and in few countries over the past few decades, which is disturbing in view of our increasing insight into long-term risk factors of coronary heart disease and the dramatic improvement in the acute therapy of its manifestations. One important reason for this is the high fatality during the initial hours of a coronary event, i.e. before medical treatment can be provided. Approximately one quarter of all patients suffering an acute cardiac event die prior to admission to hospital.
As a result, the focus of current research has shifted from after-the-fact therapy to the triggering phase of acute coronary disease. Epidemiological observations of recent trends and newly identified determinants of coronary disease and the results of substantial pathophysiological studies of the conversion from chronic coronary disease to an acute event provide the basis for new hypotheses about the triggering mechanisms. The ultimate goal is to design more effective preventive strategies for these deadly diseases.
The present extensive summary of important scientific and clinical developments in the study of the triggering and prevention of coronary syndromes that have been seen over the last ten years contains the contributions of leading experts in the field. It presents a cooperative, balanced view derived from physicians and researchers in the U.S. and Europe.

Industry Reviews

` ... concise and well written. References are up-to-date. ... can be recommended to all clinicians involved in the care of the acute coronary patient.'
Cardiologie, 3 (1996)

Foreword
Epidemiology
Magnitude of cardiovascular disease: impact and prevention in populations
Secular trends and declining mortality rates from coronary heart disease in the United States
Circadian variation in the incidence of transient myocardial ischemia
Circadian variation in the onset of myocardial infarction and sudden cardiac death
Triggering of myocardial infarction by physical activity, emotional stress and sexual activity
Physical activity, time of awakening, and other possible triggers of sudden cardiac death
Subacute psychobiological factors predisposing to triggering of coronary syndromes
Physiology
The genetic contribution to the onset of acute coronary heart disease
Hemostatic risk factors for cardiovascular disease
The imbalance of coagulation and fibrinolysis in coronary heart disease and its known risk factors
Mechanisms contributing to the abrupt conversion from stable to unstable angina and myocardial infarction
Circadian fluctuation of fibrinolytic factors in blood
Investigation, importance and clinical consequences
The role of thrombosis in acute coronary heart disease
The role of coronary vasomotor tone in coronary artery disease
Pathology
Models of the intracoronary pathogenesis of acute coronary heart disease
Some thoughts on the causes of coronary thrombosis in atherosclerotic arteries and on the research necessary for their future exploration
Determinants of rupture of atherosclerotic coronary lesions
Prevention
Primary prevention of triggering of coronary heart disease
Chronopharmacological aspects of coronary heart disease
Prehospital care of acute coronary heart disease
Pharmacological and invasive therapy for acute myocardial infarction
The role of electrophysiology and pharmacotherapy in prevention of factors triggering sudden cardiac death
Secondary prevention of myocardial infarction, the roles of bgr;-adrenergic blockers, calcium-channel blockers, angiotensin converting enzyme inhibitors, and aspirin
Gene therapy for the vulnerable atherosclerotic plaque
Index
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780792336051
ISBN-10: 0792336054
Series: Developments in Cardiovascular Medicine
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 430
Published: 30th November 1995
Publisher: SPRINGER VERLAG GMBH
Country of Publication: NL
Dimensions (cm): 23.39 x 15.6  x 2.54
Weight (kg): 0.81

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