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Transcription Factors : Handbook of Experimental Pharmacology - Manfred Gossen

Transcription Factors

Handbook of Experimental Pharmacology

By: Manfred Gossen (Editor), Jorg Kaufmann (Editor), Steven J. Triezenberg (Editor)

Hardcover Published: 1st October 2004
ISBN: 9783540210955
Number Of Pages: 581

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Transcription factors are key players in the execution of the genomic program of any given cell. Their control over complex patterns of gene expression governs essentially every step in the development, growth and differentiation of an organ- ism as well as its physiological responses to external stimuli. An Introduction to Transcription Factors, the first part of this volume, de- scribes the varied and combinatorial mechanisms involved in the two basic modes of transcriptional control, activation (the chapter by Herrera et al.) and repression (the chapter by Arnosti). Overlaying both modes is an emerging emphasis on epigenetic regulation that uses intricate patterns of chromatin modi- fication. Although many of these mechanisms have been elucidated by studying prototypical genes or transcription factors, the recently developed tools of ge- nomic biology allow us to unravel the complexity of global transcriptional pro- grams with an ever-increasing speed and accuracy (the chapter by Zacharewski and La Pres). Given the central role that transcription factors playas relays positioned be- tween the genome and the intracellular and extracellular signals to which cells must respond, it is not surprising that these regulatory proteins playa major role in pathological processes. Part 2 of this volume, Transcription Factors in Patho- physiology, introduces a selection of specific transcription factors and their families. Each of these factors has a well-established function in basic cellular mechanisms that, upon dysregulation, can cause or contribute to human disease.

An Introduction to Transcription Factors
Mechanisms of Transcriptional Activation in Eukaryotesp. 3
Multiple Mechanisms of Transcriptional Repression in Eukaryotesp. 33
Genomic Approaches to the Study of Transcription Factorsp. 69
Transcription Factors in Pathophysiology
Biological Roles of the STAT Family in Cytokine Signalingp. 97
Members of the T-Cell Factor Family of DNA-Binding Proteins and Their Roles in Tumorigenesisp. 123
Transcription Factors in the Control of Tumor Development and Progression by TGF-ß Signalingp. 167
The p53 Transcription Factor as Therapeutic Target in Cancerp. 209
The Role of Ets Transcription Factors in Mediating Cellular Transformationp. 259
Function of the E2F Transcription Factor Family During Normal and Pathological Growthp. 277
c-Myc in Cellular Transformation and Cancerp. 309
NF-B: Critical Regulator of Inflammation and the Immune Responsep. 325
Hepatitis B Virus X Protein: Structure-Function Relationships and Role in Viral Pathogenesisp. 377
Regulation of Xenobiotic Detoxification by PXR, CAR, GR, VDR and SHP Receptors: Consequences in Physiologyp. 409
Exogenous Control of Transcription Factor Activity
Potential of Transcription Factor Decoy Oligonucleotides as Therapeutic Approachp. 439
Selective Estrogen Receptor Modulators as Therapeutic Agents in Breast Cancer Treatmentp. 455
Artificial Zinc Finger Peptides: A Promising Tool in Biotechnology and Medicinep. 491
Tetracycline-Controlled Transactivators and Their Potential Use in Gene Therapy Applicationsp. 509
Modulating Transcription with Artificial Regulatorsp. 535
Subject Indexp. 573
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9783540210955
ISBN-10: 3540210954
Series: Handbook of Experimental Pharmacology
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 581
Published: 1st October 2004
Publisher: Springer-Verlag Berlin and Heidelberg Gmbh & Co. Kg
Country of Publication: DE
Dimensions (cm): 23.39 x 15.6  x 3.33
Weight (kg): 1.01