The investigation of indoor air quality has shown that microbial contamination is often a problem in buildings. Recent evidence indicates that fungi are often a part of the picture. A component of the fungal cell wall, 1A(R)3-A-glucans not only affect human health, they are a marker for the existence of fungi in environmental samples.
Toxicology of 1A(R)3-A-Glucans covers the basic chemistry and immunobiology of these substances. The authors begin by introducing current methods for detecting 1A(R)3-A-glucans in environmental samples and reviewing risk evaluation in the environment. They go on to discuss numerous topics including likely occupational and environmental exposure, studies suggesting a strong link between environmental glucan concentrations and pulmonary inflammation, and signal transduction pathways and specific receptors.
No other book currently available brings together the expertise of leading international researchers to provide a straightforward monograph on the toxicology of 1A(R)3-A-glucans. It pulls together current knowledge of these compounds, their effects, measurement, monitoring, and risk assessment.
|Introduction to the chemistry and immunobiology of [beta]-glucans||p. 1|
|Health effects of (1 -> 3)-[beta]-D-glucans : the epidemiological evidence||p. 35|
|(1 -> 3)-[beta]-D-glucan in the environment : a risk assessment||p. 53|
|Animal model of (1 -> 3)-[beta]-glucan-induced pulmonary inflammation in rats||p. 65|
|[beta]-glucan receptor(s) and their signal transduction||p. 95|
|Fate of [beta]-glucans in vivo : organ distribution and degradation mechanisms of fungal [beta]-glucans in the body||p. 109|
|Adjuvant effects of [beta]-glucans in a mouse model for allergy||p. 127|
|Endogenous septic shock by combination of [beta]-glucan and NSAIDs||p. 143|
|Particulate and soluble [beta]-glucans from Candida albicans modulate cytokine release from human leukocytes||p. 161|
|Detection and measurement of (1 -> 3)-[beta]-D-glucan with limulus amebocyte lysate-based reagents||p. 179|
|Clinical utilization of the measurement of (1 -> 3) -[beta]-D-glucan in blood||p. 199|
|Table of Contents provided by Blackwell. All Rights Reserved.|
Number Of Pages: 232
Published: 18th March 2005
Publisher: Taylor & Francis Ltd
Country of Publication: GB
Dimensions (cm): 23.5 x 15.6 x 2.54
Weight (kg): 0.48
Edition Number: 1