This book provides a comprehensive overview of structural and molecular changes induced by an invasive CNS lesion, and their involvement in regeneration processes. It also demonstrates the strong growth-promoting actitivies of implanted glial cells; these studies could have major practical importance in the development of novel therapeutic strategies. This book also presents various analyses of lesion-induced reactions.
Axonal regeneration in the adult mammalian CNS; aims of the study; materials and methods; cell culture techniques; surgical procedures; tissue procedures; tissue processing; histological methods; immuno-histochemical methods; in-situ-hybridization; quantitative analysis; results; unlesioned postcommissural fornix; sequence of cellular and molecular reactions following axonal transection; glial cell implantations; discussion; role of lesion-induced cellular and molecular changes in degeneration and regeneration; the impact of glial implants on axonal regeneration; summary and perspectives.
Series: Advances in Anatomy, Embryology and Cell Biology
Number Of Pages: 82
Publisher: Springer-Verlag Berlin and Heidelberg Gmbh & Co. Kg
Country of Publication: DE
Dimensions (cm): 23.39 x 15.6
Weight (kg): 0.14