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The Ovary - Adashi

Hardcover Published: 19th October 2018
ISBN: 9780128132098
Number Of Pages: 625

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The Ovary, Third Edition includes over 60% new material and expands the sections dealing with clinical aspects of human ovarian functions and highlights advances in the areas of genomics, assisted reproductive technology, and cancer diagnosis and treatment. This new edition synthesizes all of this new information at the molecular, cellular, and organismal levels and presents modern ovarian physiology in a more understandable and comparative context.

The Ovary, Third Edition looks at ovarian function from a detailed molecular and cellular level. This work examines in detail all phases of the ovarian life cycle, placing special emphasis on the pathophysiology of the human ovary, including ovarian carcinogenesis.

  • Represents an unparalleled compilation of chapters relevant to contemporary ovarian physiology
  • Provides basic and clinical research on ovarian function, abnormalities, assisted reproductive technology, and cancer
  • Highlights contemporary strategies and treatment paradigms in female factor infertility

Part I. The Ovarian Follicular Apparatus: Operational Characteristics 1. Follicle Selection in Mammalian Ovaries 2. Regulation of follicle formation and development by ovarian signaling pathway 3. Human Folliculogenesis Revisited: The Menstrual Cycle Visualized by Ultrasonography 4. Development of the Mammalian Ovary and Follicles 5. Organization of Ovarian Steroidogenic Cells and Cholesterol Metabolism 6. Inhibin, Activin and Follistatin in Ovarian Physiology 7. Cell-cell Interactions in the Ovarian Follicles: Role of TGF-beta Superfamily Members 8. Mutations and Polymorphisms, and their Functional Consequences, in Gonadotropin and Gonadotropin Receptor Genes 9. Environmentally Induced Epigenetic Transgenerational Inheritance of Ovarian Disease

Part II. Oocyte Maturation and Ovulation 10. Mammalian Oogenesis - the fragile foundation of the next generation 11. Mammalian Oocyte Meiosis and Chromosome Stability 12. Oocyte Meiotic Maturation 13. Gene Expression During Oogenesis and Oocyte Development 14. Oocyte Development and Ovulation

Part III. The Corpus Luteum 15. Molecular Regulation of Progesterone Production in Corpus Luteum 16. Corpus Luteum Formation 17. Luteolysis and The Corpus Luteum of Pregnancy

Part IV. Novel Experimental Models 18. Transgenic Mouse Models in the Study of Ovarian Function 19. Genome-Wide Association Studies of Ovarian Function Disorders 20. Mitchondria Research in Human Reproduction 21. Reconstitution In Vitro of Oogenesis from Pluripotent Stem Cells 22. The Role of Mitochondria in Reproductive Function and Assisted Reproduction

Part V. Human Ovarian Pathophysiology: Select Aspects 23. Ovarian Hyperstimulation Syndrome 24. The Role of GnRH Agonist Triggering in GnRH Antagonist-Based Ovarian Stimulation Protocols 25. The Ovarian Factor in Assisted Reproductive Technology 26. The Role of Antimullerian Hormone in Assisted Reproduction 27. Polycystic Ovary Syndrome 28. Genetic and Environmental Factors in the Aetiology of Polycystic Ovary Syndrome 29. Germ Cell Failure and Ovarian Resistance: Human Genes and Disorders 30. Environmental Contaminants and Ovarian Toxicity 31. Autologous Transplantation of Human Ovarian Tissue 32. Oncofertility: Preservation of ovarian function after a cancer diagnosis

Part VI. Human Ovarian Cancer 33. Ovarian cancers: their varied origins and pathologically implicated microenvironment 34. Phenotypic Plasticity and the Origins and Progression of Ovarian Cancer 35. Novel Therapeutic Approaches and Targets for Ovarian Cancer 36. Molecular and Cellular Basis of Chemoresistance in Ovarian Cancer

ISBN: 9780128132098
ISBN-10: 0128132094
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 625
Published: 19th October 2018
Publisher: Elsevier Science Publishing Co Inc
Country of Publication: US
Dimensions (cm): 27.64 x 21.59
Weight (kg): 1.95
Edition Number: 3