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The Nucleolus : Molecular Biology Intelligence Unit - Mark O. J. Olson

The Nucleolus

Molecular Biology Intelligence Unit

By: Mark O. J. Olson (Editor)

Hardcover Published: 3rd August 2004
ISBN: 9780306478734
Number Of Pages: 364

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As the first comprehensive overview of the nucleolus since 1985, The Nucleolus covers our current understanding of the cell nucleolus, including its role in ribosome assembly and its additional newly-discovered activities. The eighteen chapters have been written by experts who are actively engaged in research on the nucleolus and have an in depth review of the following topics:

- nucleolar ultrastructure and dynamics,
- behavior during mitosis,
- ribosomal DNA gene and chromatin structure,
- pre-ribosomal RNA transcription,
- processing and modification,
- ribosome assembly,
- small nucleolar RNAs,
- proteomics and non-traditional functions of the nucleolus.

Separate chapters are also provided for yeast and higher eukaryotes on many topics.
The Nucleolus will appeal not only to scientists directly engaged in nucleolar research, but also those working in related areas such as gene expression, protein biosynthesis, ribosome structure, transcription, chromatin structure, molecular genetics and the structure and functions of the cell nucleus in general.

Introductionp. 1
Nucleolar ultrastructure in vertebratesp. 10
The nucleolar ultrastructure in yeastp. 21
Dynamics of nucleolar componentsp. 29
Behavior of the nucleolus during mitosisp. 41
Structure and organization of vertebrate ribosomal DNAp. 58
The structure of rDNA chromatinp. 73
Ribosomal DNA transcription in mammalsp. 88
Transcription of rDNA in the yeast Saccharomyces cerevisiaep. 128
Three-dimensional organization of rDNA and transcriptionp. 154
Pre-ribosomal RNA processing in multicellular organismsp. 170
Pre-ribosomal RNA processing and assembly in Saccharomyces cerevisiac : the machine that makes the machinep. 199
The snoRNP's and related machines : ancient devices that mediate maturation of rDNA and other RNAsp. 223
Ribosomal subunit assemblyp. 258
Nuclear export of ribosomal subunitsp. 286
Proteomics of the nucleolusp. 302
Trafficking of spliceosomal small nuclear RNAs through the nucleolusp. 315
Nontraditional roles of the nucleolusp. 329
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780306478734
ISBN-10: 0306478730
Series: Molecular Biology Intelligence Unit
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 364
Published: 3rd August 2004
Publisher: Springer Science+Business Media
Country of Publication: US
Dimensions (cm): 23.5 x 15.5  x 2.54
Weight (kg): 0.77