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The Nramp Family : Molecular Biology Intelligence Unit - Mathieu Cellier

The Nramp Family

Molecular Biology Intelligence Unit

By: Mathieu Cellier (Editor), Philippe Gros (Editor)

Hardcover

Published: 25th August 2004
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This book is the first comprehensive volume on the "Nramp family", highlighting the physiological importance of Nramp proteins as metal transporters. The molecular knowledge of these membrane proteins is presented from an evolutionary perspective, considering Nramp cellular function and mechanism of transport in key model organisms. The pathological significance of Nramp genetic polymorphism is discussed with emphasis on metal homeostasis and microbial infection. The chapters were contributed by leading investigators, providing a timely state of the art book in this rapidly growing field.

The Nramp Family will be useful to a broad community of scientists interested in metal transport and molecular biology. It will be of interest to the research audience in the broad fields of metal ions and molecular medicine.

Preface
Mouse Natural Resistance Associated Macrophage Protein 1 (Nramp1): A Key Player in Host Innate Immunity Against Infections
Why Mouse Models? Nramp1: A Mouse Host Resistance Locus
Pathogens Under Nramp1 Control
Nramp1 Gene and Protein Expression in Macrophages
The Nramp Gene Family
Divalent Cation Transport by Nramp Proteins
Nramp1 Dependent Divalent Cations Transport at the Phagosomal Membrane
Structure/Function Studies by Site Directed Mutagenesis
Divalent Cation Transport and Resistance to Infections
Nramp1 and Phagosomal Maturation
Genetic Susceptibility to Infectious Diseases Linked to NRAMP1 Gene in Farm Animals
Comparative Genomics
Nramp1
Chicken Genomics, Salmonella Infection and NRAMP1
Bovine Genomics, Brucella abortus Infection and NRAMP1
The NRAMP Genes and Human Susceptibility to Common Diseases
NRAMP1 Gene Location and Structure
NRAMP1 Polymorphisms
NRAMP1 Function
NRAMP1 and Infectious Diseases Susceptibility
NRAMP1 and Autoimmune Diseases Susceptibility
NRAMP2 Location and Genomic Structure
NRAMP2 Functions
NRAMP2 Polymorphisms
NRAMP2 Polymorphisms and Human Diseases Susceptibility
Pleiotropic Effects of Nramp (Bcg/Lsh/Ity) Gene Expression on Macrophage Functions
Resistance to Three Pathogens Controlled by One Gene
Bcg/Lsh/Ity Gene Expression in Macrophage
Bcg/Lsh/Ity Gene Pleiotropic Effects on Macrophage Functions
Nramp, a Candidate Gene for Bcg/Lsh/Ity Gene
Impact of Nramp Gene Expression on Macrophage
Signaling Activity and Functions Regulation
Role of Nramp Family in Pro-Inflammatory Diseases
Genetic Associations with Pro-Inflammatory Autoimmune Disease in Man
Evidence for Gene x Environment Interactions?
Searching for the Functional Polymorphisms in SLC11A1
Relating Disease Phenotypes to Pleiotropic Effects of SLC11A1
A Direct Role for Iron in SLC11A1 Regulated Autoimmune
Disease Phenotypes?
Mouse Models to Study Slc11a1 Regulation of Pro-Inflammatory Diseases
Role of Nramp2 (DMT1) in Iron Homeostasis
Mammalian Iron Metabolism
Roles of Nramp2 (DMT1) in Iron Homeostasis
Nramp2 (DMT1) in Iron Disorders
Molecular Physiology of the H+-coupled Iron Transporter DMT1
Molecular Mechanisms of DMT1
Substrate Profile
Structure-Function Analysis of DMT1
The Role of DMT1 in the Biology of Iron Transport
Multiple Splice Forms Reveal Discrete Expression
Control Mechanisms
DMT1 and its Association with Human Disease
Cellular and Tissue Expression of Rat DMT1 Nramp
Gastrointestinal Tract
Liver
Erythroid Tissue
Brain
Kidney
Placenta
Tissue Distribution and Subcellular Localization of Nramp Proteins
NRAMP1: Discovery of the Nramp1 Gene
Tissue and Cellular Expression of Mouse and Human Nramp1 mRNA
Cellular and Subcellular Expression of the Nramp1 Protein in Macrophages and in Neutrophils
NRAMP2: Nramp2/DMT1 gene, RNA and Protein Isoforms
Topology Model of Nramp2/DMT1 Protein
Nramp2/DMT1: Ubiquitous and Cell Specific Expression
Nramp2/DMT1 in Epithelial Cells
Nramp2/DMT1 in Peripheral Tissues
Nramp2/DMT1 Studies: Rich but Controversial Literature
Plant Metal Transporters with Homology to Proteins of the NRAMP Family
Genomic Analysis of the NRAMP Family in Plant Species
Functional Characterization of NRAMP Metal Transport
Properties in Heterologous Expression Systems
NRAMP Gene Expression Pattern and Regulation in Plants
Analysis of NRAMP Fun
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780306478413
ISBN-10: 0306478412
Series: Molecular Biology Intelligence Unit
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 200
Published: 25th August 2004
Publisher: Springer Science+Business Media
Country of Publication: US
Dimensions (cm): 23.5 x 15.5  x 1.27
Weight (kg): 1.08