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The Neurobiology of Opiates : Physiology of Substance Abuse - Ronald P. Hammer Jr

The Neurobiology of Opiates

Physiology of Substance Abuse

Hardcover Published: 24th November 1992
ISBN: 9780849379321
Number Of Pages: 432

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This collection of reports by eminent researchers provides a complete description of the effects of opiates on the central nervous system of developing and adult animals. The work is useful to investigators interested in opiate neurobiology and clinicians seeking to understand opiate abuse.
The Neurobiology of Opiates is organized into sections which describe the wide diversity of opiate actions from cellular and molecular to developmental and behavioral. Normal functions of endogenous opioid peptides and functional effects of exogenous opiate exposure are examined using the latest in vivo and in vitro methods. Particular emphasis is placed on the physiological and pharmacological effects of opiate dependence and withdrawal, in addition to the mechanism of opiate reinforcement and molecular mechanisms of opiate regulation. Opiate actions on the developing brain and in the hypothalamo-pituitary-adrenal axis are also discussed. This comprehensive text provides readers with the latest results and challenges them with new directions for opiate research.

Developmental Effects of Opiates
Effects of Opioids on the Developing Brainp. 1
Opiates and the Regulation of Nervous System Development: Evidence from in vitro Studiesp. 23
Reinforcing Properties of Opiates during Early Developmentp. 63
Ontogeny and Plasticity of Opioid Systemsp. 85
Cellular Effects of Opiates
Opiate Receptor Regulation by Opiate Agonists and Antagonistsp. 125
Anti-Opioid Peptides in Morphine Tolerance and Dependencep. 147
Functional Anatomy of Opiate Withdrawalp. 165
Opiates Influence Locus Coeruleus Neurons by Potent Indirect and Direct Actionsp. 175
Excitatory Amino Acids Interact with Opioid Peptides to Regulate Neuronal Excitability and Gene Expression in the Rat Hippocampal Formationp. 203
Molecular Effects of Opiates
Regulation of Opioid Peptides by Self-Administered Drugsp. 223
Stimulus-Transcription Coupling at the [mu] Opiate Receptorp. 257
Opiate Regulation of Signal Transduction Pathwaysp. 301
Behavioral Effects of Opiates
Neurobiological Substrates of Opioid Abusep. 333
Reinforcing Effects of Opiates - Modulation by Dopaminep. 361
Indexp. 393
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780849379321
ISBN-10: 0849379326
Series: Physiology of Substance Abuse
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 432
Published: 24th November 1992
Country of Publication: US
Dimensions (cm): 24.64 x 16.2  x 2.31
Weight (kg): 0.89
Edition Number: 1

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