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The Neurobiology of Alzheimer's Disease : Molecular & Cellular Neurobiology Series - David Dawbarn

The Neurobiology of Alzheimer's Disease

Molecular & Cellular Neurobiology Series

By: David Dawbarn (Editor), Shelley J. Allen (Editor)


Published: 1st June 2007
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Alzheimer's disease is the most common form of dementia in the elderly; 450,000 people in the UK and 4.5 million people in the USA suffer with this disease. This 3rd edition of Neurobiology of Alzheimer's Disease gives a comprehensive and readable introduction to the disease, from molecular pathology to clinical practice.
The book is intended for readers new to the field, and it also covers an extensive range of themes for those with in-depth knowledge of Alzheimer's disease. It will therefore act either as an introduction to the whole field of neurodegeneration or it will help experienced researchers to access the latest research in specialist topics. Each chapter is written by eminent scientists leading their fields in neuropathology, clinical practice and molecular neurobiology; appendices detail disease-associate proteins, their sequences, familial mutations and known structures.
It will be essential reading for students interested in neurodegeneration and for researchers and clinicians, giving a coherent and cohesive approach to the whole area of research, and allowing access at different levels. For those in the pharmaceutical industry it describes the underlying molecular mechanisms involved in the pathogenesis of Alzheimer's disease and explains how current and potential therapeutics may work.

From reviews of the previous edition: `I have no doubt that this book has easily achieved its aims... of providing an accessible overview and a readable introduction to Alzheimer's disease... I will recommend it most enthusiastically to my students and colleagues alike.' Brain `This book will appeal to the broad readership that it is intended for including researchers and clinicians.' International Journal of Geriatric Psychiatry

1: Shelley J Allen: Alzheimer's disease: a hundred years of investigation 2: Margaret M Esiri: The neuropathology of Alzheimer's disease 3: Alison M Goate: Molecular genetics of Alzheimer's disease 4: Edward B Lee & Virginia M-Y Lee: Biology and molecular neuropathology of beta-amyloid protein 5: Khalid Iqbal, Alejandra del C Alonso, M Omar Chohan, Ezzat El-Akkad, Cheng-Xin Gong, Sabiha Khatoon, Fei Liu & Inge Grundke-Iqbal: The molecular basis of tau protein pathology: role of abnormal hyperphosphorylation 6: Agueda Rostagno, Ratnesh Lal & Jorge Ghiso: Protein misfolding, aggregation and fibril formation: common features of cerebral and non-cerebral amyloidosis 7: Suzanne E Wahrle & David M Holtzman: Apolipoprotein E, amyloid beta-peptide and Alzheimer's disease 8: Kulandaivelu S Vetrivel & Gopal Thinakaran: Presenilins 9: Dick Terwel, Ilse Dewachter, Tom van Dooren, Tom Vandebroek, Thomas Van Helmont, David Muyllaert, Peter Borghgraef, Sophie Croes, Joris Winderickx & Fred van Leuven: Multiple transgenic mouse models for Alzheimer's disease 10: Mark P Mattson: Inflammation and Alzheimer's disease 11: Xi Chen, David Stern & Shi Du Yan: Cellular targets of amyloid beta-peptide: potential roles in neuronal cell stress and toxicity 12: Mitchell K P Lai, Maria J Ramirez, Shirley W Y Tsang & Paul T Francis: Alzheimer's disease as a neurotransmitter disease 13: Elliott J Mufson, Scott E Counts, Margaret Fahnestock & Stephen D Ginsberg: NGF family of neurotrophins and their receptors: early involvement in the progression of Alzheimer's disease 14: Sarmishtha Bhattacharyya, Ros Overshott & Alistair Burns: Clinical assessment of Alzheimer's disease 15: Henrik Zetterburg & Kaj Blennow: Molecular and biological markers for Alzheimer's disease 16: Gordon K Wilcock & David Dawbarn: Current pharmacological approaches to treating Alzheimer's disease 17: Weiming Xia: Amyloid-based therapies 18: Colin L Masters: Future directions: the A-beta amyloid pathway as the target for diagnosing, preventing or treating Alzheimer's disease

ISBN: 9780198566618
ISBN-10: 0198566611
Series: Molecular & Cellular Neurobiology Series
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 488
Published: 1st June 2007
Publisher: Oxford University Press
Country of Publication: GB
Dimensions (cm): 25.4 x 17.8  x 3.1
Weight (kg): 0.99
Edition Number: 3
Edition Type: Revised