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The Mouse in Biomedical Research Volume 3, 2E : Normative Biology, Husbandry, and Models - James G. Fox

The Mouse in Biomedical Research Volume 3, 2E

Normative Biology, Husbandry, and Models

Hardcover Published: 30th November 2006
ISBN: 9780123694577
Number Of Pages: 816

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Normative Biology, Husbandry, and Models, the third volume in the four volume set, The Mouse in Biomedical Research, encompasses 23 chapters whose contents provide a broad overview on the laboratory mouse's normative biology, husbandry, and its use as a model in biomedical research. This consists of chapters on behavior, physiology, reproductive physiology, anatomy, endocrinology, hematology, and clinical chemistry. Other chapters cover management, as well as nutrition, gnotobiotics and disease surveillance. There are also individual chapters describing the mouse as a model for the study of aging, eye research, neurodegenerative diseases, convulsive disorders, diabetes, and cardiovascular and skin diseases. Chapters on imaging techniques and the use of the mouse in assays of biological products are also included.

History, Wild Mice, and Genetics
List of Reviewersp. x
List of Contributorsp. xi
Forewordp. xiii
Prefacep. xv
Building a Better Mouse: One Hundred Years of Genetics and Biologyp. 1
Systematics of the genus Musp. 13
The Secret World of Wild Micep. 25
Breeding Systems: Considerations, Genetic Fundamentals, Genetic Background, and Strain Typesp. 53
Mouse Strain and Genetic Nomenclature: an Abbreviated Guidep. 79
The Mouse Genomep. 99
Gene Mappingp. 115
Genetic Monitoringp. 135
Cytogeneticsp. 145
Mouse Embryology: Research Techniques and a Comparison of Embryonic Development between Mouse and Manp. 165
Gamete and Embryo Manipulationp. 211
Chemical Mutagenesis in Micep. 225
Gene-Specific Mutagenesisp. 261
Gene Transfer Studies Using Mouse Modelsp. 267
Mouse and Human Pluripotent Stem Cellsp. 281
Drugs and the Mouse: Pharmacology, Pharmacogenetics, and Pharmacogenomicsp. 289
Indexp. 321
List of Reviewersp. x
List of Contributorsp. xi
Forewordp. xiii
Prefacep. xv
Viral Diseases
DNA Viruses
Murine Cytomegalovirus and Other Herpesvirusesp. 1
Mouse Adenovirusesp. 49
Mousepoxp. 67
Parvovirusesp. 93
Polyoma Virusesp. 105
RNA Viruses
Mouse Hepatitis Virusp. 141
Lymphocytic Choriomeningitis Virusp. 179
Lactate Dehydrogenase-Elevating Virusp. 215
Reoviridaep. 235
Retroelements in the Mousep. 269
Sendai Virus and Pneumonia Virus of Mice (PVM)p. 281
Cardioviruses: Encephalomyocarditis Virus and Theiler's Murine Encephalomyelitis Virusp. 311
Bacterial Diseases
Chlamydial Diseasesp. 325
Clostridial Speciesp. 349
Enterobacteriaceae, Pseudomonas aeruginosa, and Streptobacillus moniliformisp. 365
Aerobic Gram-Positive Organismsp. 389
Helicobacter Infections in Micep. 407
Mycoplasma pulmonis, Other Murine Mycoplasmas, and Cilia-Associated Respiratory Bacillusp. 437
Pasteurellaceaep. 469
Mycotic and Parasitic Diseases
Fungal Diseases in Laboratory Micep. 507
Protozoap. 517
Helminth Parasites of Laboratory Micep. 551
Arthropodsp. 565
Miscellaneous Diseases
The Tumor Pathology of Genetically Engineered Mice: A New Approach to Molecular Pathologyp. 581
Spontaneous Diseases in Commonly Used Mouse Strainsp. 623
Zoonoses and Other Human Health Hazardsp. 719
Indexp. 747
Normative Biology, Husbandry, and Models
List of Reviewersp. x
List of Contributorsp. xi
Forewordp. xiv
Prefacep. xv
Normative Biology
Gross Anatomyp. 1
Mouse Physiologyp. 23
Reproductive Biology of the Laboratory Mousep. 91
Endocrinology: Bone as a Target Tissue for Hormonal Regulationp. 123
Hematology of the Laboratory Mousep. 133
Clinical Chemistry of the Laboratory Mousep. 171
Management, Techniques, and Husbandry
Gnotobioticsp. 217
Management and Design: Breeding Facilitiesp. 235
Design and Management of Research Facilities for Micep. 271
Nutritionp. 321
Health Delivery and Quality Assurance Programs for Micep. 385
Environmental and Equipment Monitoringp. 409
Biomethodology and Surgical Techniquesp. 437
In-Vivo Whole-Body Imaging of the Laboratory Mousep. 489
Use of Mice in Biomedical Research
Behavioral Testingp. 513
Cardiovascular Disease: Mouse Models of Atherosclerosisp. 535
Convulsive Disordersp. 565
Eye Researchp. 595
Genetic Analysis of Rodent Obesity and Diabetesp. 617
Mouse Models in Aging Researchp. 637
Mouse Models of Inherited Human Neurodegenerative Diseasep. 673
Mouse Skin Ectodermal Organsp. 691
Quality Control Testing of Biologicsp. 731
Indexp. 759
List of Reviewersp. x
List of Contributorsp. xi
Forewordp. xiii
Prefacep. xv
Overviewp. 1
The Molecular Basis of Lymphoid Architecture in the Mousep. 57
The Biology of Toll-Like Receptors in Micep. 109
Genomic Organization of the Mouse Major Histocompatibility Complexp. 119
Some Biological Features of Dendritic Cells in the Mousep. 135
Mouse Models Revealed the Mechanisms for Somatic Hypermutation and Class Switch Recombination of Immunoglobulin Genesp. 155
Mouse Natural Killer Cells: Function and Activationp. 169
Cytokine-Activated JAK-STAT Signaling in the Mouse Immune Systemp. 179
Signal Transduction Events Regulating Integrin Function and T Cell Migration in the Mousep. 195
Mouse Models of Negative Selectionp. 207
Peripheral Tolerance of T Cells in the Mousep. 223
The Genetics of Mouse Models of Systemic Lupusp. 243
Inhibitory Receptors and Autoimmunity in the Mousep. 261
Mouse Models of Immunodeficiencyp. 275
Mouse Models to Study the Pathogenesis of Allergic Asthmap. 291
The Mouse Trap: How Well Do Mice Model Human Immunology?p. 303
Indexp. 313
Table of Contents provided by Ingram. All Rights Reserved.

ISBN: 9780123694577
ISBN-10: 0123694574
Series: American College of Laboratory Animal Medicine : Book 3
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 816
Published: 30th November 2006
Publisher: Elsevier Science Publishing Co Inc
Country of Publication: US
Dimensions (cm): 27.9 x 21.6  x 3.81
Weight (kg): 2.1
Edition Number: 2
Edition Type: Revised