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The Molecular and Supramolecular Chemistry of Carbohydrates : A Chemical Introduction to the Glycosciences - Serge David

The Molecular and Supramolecular Chemistry of Carbohydrates

A Chemical Introduction to the Glycosciences

By: Serge David, Rosemary Green Beau (Translator)

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Current research in carbohydrates is beginning to range across traditional divisions in chemistry and biology, giving rise to a new interdisciplinary field, glycoscience. The growing interest in glycoscience stems from the discovery that oligosaccharides play an important role in recognition events and from the growing demand for chiral synthesis, since sugars can provide an amazingly cheap source of chiralitiy. This book is the first unified treatment of glycoscience within the framework of organic chemistry. It also offers a wealth of supramolecular associations from carbohydrate chemistry. Unique among texts on carbohydrates, it devotes half of its content to important examples of such interactions.
The book begins with a discussion of the configuration, conformation, derivatization, and modifications of monosaccharides. It includes examples of their use in total synthesis and a detailed discussion of the anomeric effect, the most popular of all stereoelectronic effects and a powerful tool for chemists. The next chapters focus on oligosaccharides. They cover the essentials of enzymic synthesis, with its high performances. One chapter is devoted to the sialic acids, now at the forefront of carbohydrate research. The authors describe a number of recognition reactions, among them the blood group phenomena, the interactions involving sialic acids, the active site of heparin, tumor markers and selectins. They also devote a chapter to the association of sugars with small molecules, notably with inorganic species. Throughout the book, great attention is given to practical details and experimental protocols involving unfamiliar techniques. The many tables, figures, diagrams and experimental protocols will help the reader visualize the great diversity of information.


"This book....should serve well as an introduction to this vast field, and I enthusiastically recommend it to anyone seeking to become acquainted with the glycosciences."--Journal of Medicinal Chemistry


"A complete understanding of the advances in glycoscience, the chemistry and biology of carbohydrates, requires a researcher or student to be aware of developments in many different disciplines that at first may seem unrelated. For example, since shapes of oligosaccharides on the surface of cells are important in cell recognition, a practitioner of glycoscience needs an understanding of immunology, conformational analysis, and molecular orbitals. Serge tries to unite the many different disciplines into a single short volume. The material is evenly divided between classical carbohydrate chemistry topics (configurations, conformations, chemical reactions, nomenclature, etc.) and the biological application of these topics (associations, glycoconjugates, antigens and antibodies, blood group antigens, ligands to DNA, etc.). . . . suitable for either an advanced organic chemistry graduate student expanding into the glycosciences or a practitioner of the field looking for an overall review."--Choice


"This interesting introduction to the world of the glycosciences is written by an organic chemist for organic chemists. The first of its two parts deals with the nomenclature, synthesis, structures, reactions and conformations of both mono- and oligosaccharides. Although written with organic chemists in mind, this section is very clear and readable by anyone who has a good background in chemistry. The last seven chapters in the book present some of the roles played by complex carbohydrates in biological systems. These chapters introduce glycoconjugates (glycoproteins, glycolipids, proteoglycans), sialic acids, lectins, blood groups, and sugar-protein interactions. . . . The author has specifically not written this volume as a textbook, but more as an introduction and historical reflection on a rapidly growing field. Although a translation, the book projects the author's joy and enthusiasm."--The Quarterly Review of Biology


1: Configuration of monosaccharides 2: Conformation of monosaccharides and their derivatives 3: Alkyl and aryl glycosides and glycosamines 4: Nomenclature 5: Reactions of hydroxyl groups 6: Reactions of carbonyl groups and hemiacetals 7: Changes of configuration, unsaturated and branched-chain sugars 8: Sugars in chiral synthesis 9: Oligosaccharides : configuration and analysis 10: Chemical transformations and synthesis of oligosaccharides 11: Associations with anions, cations, and inorganic molecules 12: Sialic and sialylated oligosaccharides 13: Glycoconjugates 14: Structure of some crystallized sugar-protein complexes 15: Antigens and antibodies. Lectins 16: ABH and related blood group antigens 17: Important recognition events involving oligosaccharides in the living world 18: Oligosaccharides as ligands to DNA

ISBN: 9780198500469
ISBN-10: 0198500467
Series: Oxford Science Publications
Audience: General
Format: Paperback
Language: English
Number Of Pages: 336
Published: 16th October 1997
Country of Publication: GB
Dimensions (cm): 23.5 x 15.88  x 1.91
Weight (kg): 0.5

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