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The Kidney and Hypertension in Diabetes Mellitus : Topics in Renal Medicine - Carl Erik Mogensen

The Kidney and Hypertension in Diabetes Mellitus

Topics in Renal Medicine

By: Carl Erik Mogensen (Editor)

Hardcover Published: December 2009
ISBN: 9780898389586
Number Of Pages: 423

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The first sporadic observations describing renal abnormalities in diabetes were published late in the 19th century, but systematic studies of the kidney in diabetes started only half a century ago after the paper by Cambier in 1934 and the much more famous study by Kimmelstiel and Wilson in 1936. These authors described two distinct features of renal involvement in diabetes: early hyperfiltration and late nephropathy. Diabetic nephropathy is, despite half a century of studies, still a very pertinent problem, renal disease in diabetes now being a very common cause of end-stage renal failure in Europe and North America and probably throughout the world. It is a very important part of the generalized vascular disease found in long-term diabetes as described by Knud Lundbaek in his mono graph Long-term Diabetes in 1953, published by Munks- gaard, Copenhagen. Surprisingly, there has not been a comprehensive volume describing all aspects of renal involvement in diabetes, and the time is now ripe for such a volume summarizing the very considerable research activity within this field during the last decade and especially during the last few years. This book attempts to cover practically all aspects of renal involvement in diabetes. It is written by colleagues who are themselves active in the many fields of medical research covered in this volume: epidemiology, physiology and pathophysiology, laboratory methodology, and renal pathology. New studies deal with the dia gnosis and treatment of both incipient and overt nephropathy by metabolie, antihypertensive, and dietary invention.

`This is a timely publication that will be welcomed by all clinicians ... covers all aspects of diabetic nephropathy, from epidemiology to pathophysiology and management. ... clear and concise ... This should be essential reading for all nephrologists and will find a place in the libraries of all renal units managing patients with end-stage renal failure.' Nephrology/Dialysis, 5/6

Some keys to the literaturep. xiii
Contributing authorsp. xxiii
Preface, first editionp. xxix
Preface, second editionp. xxxi
Preface, third editionp. xxxiii
Preface, fourth editionp. xxxv
Preface, fifth editionp. xxvii
Pressure induced and metabolic alterations in the glomerulus: Role in cytokine activity and progressive sclerosisp. 1
Definition of diabetic renal disease in insulin-dependent diabetes mellitus based on renal function testsp. 13
Retinopathy in relation to albuminuria and blood pressure in IDDMp. 29
Microalbuminuria and cardiovascular diseasep. 39
The heart in diabetes: results of trialsp. 55
Albuminuria in non-insulin-dependent diabetes - renal or "extra" renal disease?p. 67
The clinical course of renal disease in Caucasian NIDDM-patientsp. 81
Serum creatinine and other measures of GFR in diabetesp. 95
Familial factors in diabetic nephropathyp. 103
Genetics and diabetic nephropathyp. 115
Birth, Barker and Brenner: The concept of low birth weight and renal diseasep. 129
Effect of insulin on the kidney and the cardiovascular systemp. 141
Value of screening for microalbuminuria in people with diabetes as well as in the general populationp. 155
Incidence of nephropathy in IDDM as related to mortality. Cost and benefits of early interventionp. 169
Dysfunction of the vascular endothelium and the development of renal and vascular complications in diabetesp. 179
Urinary tract infections in patients with diabetes mellitusp. 193
Light microscopy of diabetic glomerulopathy: the classic lesionsp. 201
Renal structural changes in patients with type 1 diabetes and microalbuminuriap. 211
Renal structure in type 2 diabetic patients with microalbuminuriap. 225
Nephropathy in NIDDM patients, predictors of outcomep. 237
Advanced glycation end-products and diabetic renal diseasep. 247
Protein kinase C in diabetic renal involvement, the perspective of inhibitionp. 255
Biochemical aspects of diabetic nephropathyp. 263
Pathogenesis of diabetic glomerulopathy: the role of glomerular hemodynamic factorsp. 281
An update on the role of growth factors in the development of diabetic kidney diseasep. 295
Transforming growth factor-[beta] and other cytokines in experimental and human diabetic nephropathyp. 313
Blood pressure elevation in diabetes: the results from 24-h ambulatory blood pressure recordingsp. 339
Microalbuminuria in young patients with type 1 diabetesp. 363
Early renal hyperfunction and hypertrophy in IDDM patients including comments on early interventionp. 381
Diabetes, hypertension, and kidney disease in the Pima Indiansp. 395
Autoregulation of glomerular filtration rate in patients with diabetesp. 407
ACE-inhibition, angiotensin II receptor blockade, and diabetic nephropathyp. 417
The concept of incipient diabetic nephropathy and effect of early antihypertensive interventionp. 423
Reversibility of diabetic nephropathy lesions: A new conceptp. 435
Antihypertensive treatment in NIDDM, with special reference to abnormal albuminuriap. 441
Addendum regarding renovascular hypertension and renal artery stenosis (especially NIDDM)
The course of incipient and overt diabetic nephropathy: the perspective of more optimal treatment, including UKPDS-perspectivep. 461
Non-glycaemic intervention in diabetic nephropathy: the role of dietary protein intakep. 473
Diabetic nephropathy and pregnancyp. 487
Evolution worldwide of renal replacement therapy in diabetesp. 501
Haemodialysis and CAPD in type 1 and type 2 diabetic patients with endstage renal failurep. 513
Renal transplantation for diabetic nephropathyp. 527
Combination therapy for hypertension and renal disease in diabetesp. 559
Microalbuminuria in essential hypertension. Significance for the cardiovascular and renal systemsp. 575
A comparison of progression in diabetic and non-diabetic renal disease: similarity of progression promotersp. 587
Update of the latest intervention trials in hypertension and type 2 diabetesp. 601
Scientific basis for the new guidelines for the treatment of hypertension in type 2 diabetesp. 611
Regulatory considerations in the development of therapies for diabetic nephropathy and related conditionsp. 623
The renin angiotensin system in the pathogenesis of diabetic complicationsp. 645
Microalbuminuria, blood pressure and diabetic renal disease: Origin and development of ideasp. 655
Table of Contents provided by Syndetics. All Rights Reserved.

ISBN: 9780898389586
ISBN-10: 0898389585
Series: Topics in Renal Medicine
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 423
Published: December 2009
Publisher: Kluwer Academic Publishers
Country of Publication: US
Dimensions (cm): 23.5 x 15.5  x 2.5
Weight (kg): 1.77