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The Impact of Biotechnology on Autoimmunity : MEDICAL SCIENCE SYMPOSIA SERIES - A. G. Dalgleish

The Impact of Biotechnology on Autoimmunity


By: A. G. Dalgleish (Editor)

Hardcover Published: 28th February 1994
ISBN: 9780792327240
Number Of Pages: 137

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The term "autoimmunity" has been used to categorize a number of different diseases of unknown etiology. The term as applied to many of these diseases would probably be interpreted best as "autoreactivity," as the clinical phenotypes are often characterized by an inflammatory-like accumulation of activated cells of the immune system at sites of obvious damage of normal cells and/or tissue. The reasons as to why an immune system should attack itself are far from clear, although the association with specific infectious diseases in genetically susceptible people remains perhaps our best lead. The input of the biotechnological revolution has enabled us to attempt to readdress many of the fundamental questions raised by clinical and serological associations with autoimmune disease. The ability to dissect the immune response to these infectious agents which are associated with autoimmune features (as well as the facility to identify new agents, e. g. HIV), in addition to the ability to clone and sequence immune response genes, has enabled a much better understanding, at least of the complexity of "autoimmunity" to be gleaned. This volume contains the chapters that summarize the plenary presentations given at The Impact of Biotechnology on AUTOIMMUNI1Y meeting in Florence, Italy in June 1993. They cover all aspects from pathogenesis to treatment. The association with infectious diseases and autoimmunity is comprehensively covered by David Isenberg who reviews major issues, such as the association of autoantibodies appearing after infectious disease and antibacterial antibodies associated with autoimmune disease.

Role of HLA-DQ2 and -DQ8 as Susceptibility Molecules in Coeliac Disease - A Model-disease of Autoimmunityp. 1
Immunoglobulin V Gene Repertoire of Human B Cellsp. 7
Recent Progress in Human Natural Killer Cell Ontogenyp. 11
Role of the HLA-DQ Genotype in IDDM Susceptibilityp. 21
New Clinical and Molecular Features of "Essential" Mixed Cryoglobulinemiap. 27
Post-Streptococcal Autoimmune Sequelae: A Link Between Infection and Autoimmunityp. 37
Infection and Autoimmunity: Possible Contribution of Heat Shock Proteinsp. 51
Chronic Infection and Autoimmunityp. 61
The Role of HLA Mimicry by HIV in the Pathogenesis of AIDSp. 67
Idiotypic Induction of Autoimmune Diseases: A New Aspect of Infection and Autoimmunityp. 73
Immunopathology of Insulin-Dependent Diabetes Mellitus (IDDM)p. 81
Autoimmune Mechanisms in Rheumatoid Synovial Inflammationp. 87
Antinuclear Antibodies: Clinical and Diagnostic Relevancep. 93
TAP1 Allele Association with IDDMp. 99
Induction of Peripheral Tolerance in Primed Micep. 107
Epitope Screening Libraries: A New Strategy to Identify MHC-Specific Antagonistsp. 115
The Therapeutic Use of Anti-CD3 Monoclonal Antibodies in Autoimmune Diseases-Application to Type I Insulin-Dependent Diabetesp. 123
Engineering of IL-1 Antagonistsp. 129
Indexp. 135
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792327240
ISBN-10: 0792327241
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 137
Published: 28th February 1994
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 25.4 x 17.15  x 1.27
Weight (kg): 0.5