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The Human Immunodeficiency Virus : Biology, Immunology, and Therapy - Emilio A. Emini

The Human Immunodeficiency Virus

Biology, Immunology, and Therapy

By: Emilio A. Emini (Editor)

Hardcover

Published: 27th January 2002
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The past few years have witnessed an explosive increase in our collective knowledge of the biology of the human immunodeficiency virus (HIV). Researchers have acquired new understanding of the virus's biochemistry, molecular biology, pathogenesis, genetics, and immunobiology. Resulting therapeutic advances have significantly prolonged the lives of thousands. Yet, the need to develop better therapies is ever more acute and--given the virus's continued spread through the human population--the need for an effective vaccine is urgent.

These goals can be accomplished only through the experienced synthesis of information from the many disciplines participating in HIV research and through the insights of new investigators. This volume is designed to lower the barriers imposed on investigators by the sheer volume of available information--information that often can be found only in far-flung and specialized journals. It provides, in a single resource, an in-depth overview of the diverse areas that constitute HIV research. The result is a broad introduction for students and researchers new to the field as well as an integrated overview for researchers specialized in particular areas of HIV investigation. The volume will also benefit those seeking technical understanding of the virus's biology, including physicians treating HIV-infected patients.

Each chapter is a comprehensive presentation of one area of current AIDS research--including work on the virus life cycle, epidemiology, genetics, protease and reverse transcriptase inhibitors, receptor and co-receptor interactions, therapeutic targets, clinical treatment, immunobiology, and vaccines--written by a leading researcher in that area. The contributors are Jon P. Anderson, Jan Balzarini, Elana Cherry, Thomas J. Coates, Chris Collins, Jon H. Condra, Mark B. Feinberg, Richard B. Gaynor, Matthias Gotte, Daria J. Hazuda, Spyros Kalams, Nathaniel R. Landau, Gerald H. Learn, Norman L. Letvin, James I. Mullins, Willscott E. Naugler, David Nickle, Matthew Rain, Allen G. Rodrigo, Daniel Shriner, Shalom Spira, Mario Stevenson, Todd Summers, Catherine Ulich, Joseph P. Vacca, Mark A. Wainberg, Bruce D. Walker, and Yang Wang.

"Emini, one of the leading scientists in antiviral research, has edited an excellent treatise... Each chapter is written by an outstanding investigator in the field, and as a result this book provides an accurate and comprehensive review of the literature up to 2000."--Choice "Is it realistic to produce an up-to-date textbook on HIV and AIDS? Emilio Emini has made a brave attempt, persuading several of the best investigators in the field to write authoritative chapters... Overall, this book provides a comprehensive account of anti-HIV drugs and potential drugs and targets, based on what was known as of the end of the 1990s."--Robin A. Weiss, PH.D., New England Journal of Medicine "A useful review of immunology, and therapy of the Human Immunodeficiency Virus."--John P. Phair, Quarterly Review of Biology "A superb and comprehensive volume that summarizes all that is taking place in HIV research at the present time... [T]he leading comprehensive treatise on HIV research."--Pascal James Imperato, Journal of Community Health

Prefacep. vii
Contributorsp. xi
The Structure and Biology of HIV-1: Introductionp. 1
The Genetics of HIV-1p. 44
Nucleoside Inhibitors of HIV Reverse Transcriptase and the Problem of Drug Resistancep. 100
Non-Nucleoside Reverse Transcriptase Inhibitors of HIV-1p. 132
HIV-1 Protease Inhibitorsp. 172
The Biology and Biochemistry of Integration as a Target for Chemotherapeutic Interventionp. 223
Chemokine Receptors in HIV Infection and AIDSp. 250
Novel HIV-1 Therapeutic Targets: Regulatory Functionsp. 294
Novel HIV-1 Therapeutic Targets: Accessory Functionsp. 328
The Interface between the Pathogenesis and Treatment of HIV Infectionp. 384
HIV Prevention: Implementing Proven Prevention Interventions to Control the Global Epidemicp. 441
The Immunobiology of HIV-1 Infectionp. 459
HIV Vaccines 2000: Prospects and Challengesp. 481
Indexp. 511
Table of Contents provided by Syndetics. All Rights Reserved.

ISBN: 9780691004549
ISBN-10: 0691004544
Audience: Tertiary; University or College
Format: Hardcover
Language: English
Number Of Pages: 544
Published: 27th January 2002
Publisher: Princeton University Press
Country of Publication: US
Dimensions (cm): 25.4 x 17.8  x 4.45
Weight (kg): 1.13