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The Enigma of Slow Viruses : Facts and Artefacts :  Facts and Artefacts - P. P. Liberski

The Enigma of Slow Viruses : Facts and Artefacts

Facts and Artefacts

Paperback Published: April 1993
ISBN: 9783211824276
Number Of Pages: 277

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Scrapie, a naturally occurring neurodegenerative disease of sheep and sometimes goats, is a prototypic disease for the whole group of the subacute spongiform virus encephalopathies. Kuru was the first human disease of this type to be discovered in 1957 by Gadjusek and Zigas, and its discovery opened the whole field in the human biomedical sciences by the very realization of the fact that viruses may induce disease months or even decades after infections, and that these slow virus diseases are more compatible with classical degenerations of the nervous system than with inflammatory disorders of the brain. More than a quarter of a century since discovery of Kuru, and more than a half century following the first transmission of scrapie, the very nature of the infectious virus remains unknown. This comprehensive review covers all aspects of slow unconventional virus infections known today. It includes numerous historical data, biochemistry and molecular biology of the prion protein and its gene, the role of genetics and mutations within PrP gene, spreading and targeting of the virus, biochemistry and neurochemistry of the alterations of different neurotransmitter system and neuropathology. More than 1000 references are listed and critically analyzed; the reader can find references to all experiments and laboratory findings which has ever been done in this field. Furthermore, the book offers different views on basic problems, as for example, the nature of the scrapie agent.

Introduction: subacute spongiform virus encephalopathies from the perspective of a neuroscientistp. 1
The molecular biology of the slow virusesp. 7
The search for the virus-specific nucleic acidp. 7
The prion proteinp. 18
The structure of the gene encoding PrP 33-35 (Prn-p) in different speciesp. 46
The models of slow virusesp. 73
The pathogenesis of slow virus infectionp. 83
The general sequence of the pathogenetic eventsp. 83
The role of the spleenp. 85
The role of the spleen in neuroinvasionp. 87
The role of viremiap. 93
The role of macrophages in scrapie infectionp. 95
The neural spread of infectivity from the spleen to the central nervous systemp. 95
The neural spread of infectivity within the central nervous systemp. 98
Biochemistry and histochemistry of slow virus infectionsp. 100
Neuropathology of slow virus diseasesp. 111
Natural scrapiep. 111
Kurup. 112
Creutzfeldt-Jakob disease (CJD)p. 114
Elements of neuropathology of slow virus disordersp. 121
Final conclusionsp. 195
Addendump. 201
Referencesp. 205
Indexp. 265
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9783211824276
ISBN-10: 3211824278
Series: Archives of Virology. Supplementa
Audience: General
Format: Paperback
Language: English
Number Of Pages: 277
Published: April 1993
Country of Publication: AT
Dimensions (cm): 27.94 x 20.96  x 1.6
Weight (kg): 0.68