The Dynamic Genome : Barbara McClintock's Ideas in the Century of Genetics

Barbara McClintock's Ideas in the Century of Genetics

By: Nina Fedoroff (Editor), David Botstein (Editor)

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Paperback | 1 January 1992 | Edition Number 1

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Barbara McClintock was born in 1902, within a few years of the rediscovery of Mendel's laws. Her life, discoveries, and insights span the history of genetics in this century. McClintock's unique ability to discern relationships between the behavior of chromosomes and the properties of the whole organism earned her early recognition. At Cold Spring Harbor, she began the studies of the consequence of dicentric chromosome formation and breakage that led her to the discovery of genetic elements capable of moving within the genome and controlling expression of other genes. This book contains a kaleidoscope of contributions, many by those who discovered transposition in other organisms. Their essays give a remarkable account of the scientific legacy of one of the century's greatest geneticists.

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Introduction	p. 1
Cytogenetics
Reprint of Creighton and McClintock 1931: A Correlation of Cytological and Genetical Crossing-over in Zea mays	p. 7
Recollections of Barbara McClintock's Cornell Years	p. 13
Barbara McClintock: Reminiscences	p. 19
Barbara McClintock: Recollections of a Graduate Student	p. 25
Neurospora Chromosomes	p. 33
The Early Years of Maize Genetics	p. 45
Transposition
Reprint of McClintock 1952: Chromosome Organization and Genic Expression	p. 73
Insertion by Phages and Transposons	p. 109
Cold Spring Harbor 1944-1955: A Minimemoir	p. 115
Annals of Mobile DNA Elements in Drosophila: The Impact and Influence of Barbara McClintock	p. 117
The Mutable waxy and bronze1 Alleles of Maize	p. 123
Remembrances of Barbara McClintock	p. 133
The Nucleolar-organizing Element	p. 139
Do Some "Parasitic" DNA Elements Earn an Honest Living?	p. 145
The Plural of Heterochromatin	p. 155
A Tapestry of Transposition	p. 173
Reprint of McClintock 1956: Intranuclear Systems Controlling Gene Action and Mutation	p. 185
Retirement
Reprint of Introduction: The Discovery and Characterization of Transposable Elements: The Collected Papers of Barbara McClintock	p. 205
Kernels and Colonies: The Challenge of Pattern	p. 213
Phage Mu: An Early Prokaryotic Controlling Element	p. 223
Discovery of the Bacterial Transposon Tn10	p. 225
McClintock (1933): Implications for Meiotic Chromosome Pairing	p. 233
Twenty-five Years of Transposable Element Research in Koln	p. 243
Obsession with Sequences	p. 265
The Revenge of the Mayans	p. 273
"Please Come to My Laboratory for Better Coffee, Fresh Orange Juice,...Conversation"	p. 277
Transposable Elements (Ty) in Yeast	p. 281
Controlling Elements, Mutable Alleles, and Mating-type Interconversion	p. 289
Thinking about Programmed Genome Rearrangements in a Genome Static State of Mind	p. 299
The Role of McClintock's Controlling Element Concept in the Story of Yeast Mating-type Switching	p. 307
From Bacterial Flagella to Homeodomains	p. 315
Discovery of Tc1 in the Nematode, Caenorhabditis elegans	p. 319
Reprint of McClintock 1978: Mechanisms That Rapidly Reorganize the Genome	p. 335
The Nobel Prize and a Molecular Retrospective
Reprint of McClintock 1984: Nobel Prize Lecture: The Significance of Responses of the Genome to Challenge	p. 361
Broken Chromosomes and Telomeres	p. 381
Maize Transposable Elements: A Story in Four Parts	p. 389
Name Index	p. 417
Subject Index	p. 419
Table of Contents provided by Blackwell. All Rights Reserved.

The Dynamic Genome : Barbara McClintock's Ideas in the Century of Genetics

Barbara McClintock's Ideas in the Century of Genetics

At a Glance

Paperback

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How to return your order

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