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The Design and Analysis of Sequential Clinical Trials : Statistics in Practice - John Whitehead

The Design and Analysis of Sequential Clinical Trials

Statistics in Practice


Published: 4th August 1997
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This book details all aspects of sequential clinical trials from preliminary planning, through the monitoring of the trial, to the final analysis of the results. Emphasis is placed on the triangular test and other procedures based on straight line stopping boundaries. These methods allow for frequent or occasional interim analyses and permit the analysis of a wide variety of patient responses. Alternative procedures are also covered in detail, and these include -spending function methods, repeated confidence intervals and Bayesian approaches to sequential clinical trials.

"...This book is clear, it provides many details and is well written..." (Statistical Methods in Medical Research, No.11, 2002)

Clinical Trials.

Allocating Patients to Treatments.

Measurement of Treatment Difference.

The Design of a Sequential Trial Using the Boundaries Approach.

The Analysis of a Sequential Trial.

Alternative Approaches to the Design and Analysis of Sequential Clinical Trials.

Prognostic Factors.

The Comparison of More than Two Treatments.

Implementation of Sequential Methods: Some Examples.




ISBN: 9780471975502
ISBN-10: 0471975508
Series: Statistics in Practice
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 328
Published: 4th August 1997
Country of Publication: GB
Dimensions (cm): 23.7 x 16.05  x 2.34
Weight (kg): 0.59
Edition Number: 1
Edition Type: Revised