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The Chemical Synthesis of Peptides : International Series of Monographs on Chemistry - John Jones

The Chemical Synthesis of Peptides

International Series of Monographs on Chemistry


Published: 7th April 1994
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Peptides have many roles in medicine, and their potential for future application is even greater. They are involved in the regulation of fertility, the control of pain, the stimulation of growth, cancer therapy, cardiovascular problems, connective tissue diseases, digestive disorders, mental illness, and infections by microbial or viral agents. The preparation of such compounds by manipulating biological systems (genetic engineering) is an increasingly sophisticated art, but each case requires developmental work, and the approach is at present almost powerless with structural types that don't occur naturally. Chemical synthesis, on the other hand, is in principle applicable to any target, and is likely to remain very important in the peptide area for the foreseeable future. The emphasis throughout this book is on the chemical principles behind the more important methods of peptide synthesis. It provides a critical, concise, and up-to-date survey of the field. The term peptide is interpreted liberally, as embracing not only conventional sequences of up to a few dozen natural amino acids, but also protein-scale molecules and structures comprising other residues or unusual features, for example, cyclopeptides and conjugated peptides. The synthetic methods considered here are treated within a modern mechanistic framework, and illustrated with carefully selected case studies, and this valuable account will be of interest to all those working in the field of peptide synthesis.

'This is a good, plain, traditional book on the chemistry of peptide synthesis. It is written in classical textbook style and is full of formulae, equations and flow sheets. ...will be especially valuable for new researchers who are contemplating or starting peptide synthesis ...a good book and I strongly recommend it.' Chemistry in Britain `This book is written with elegance and precision, by an expert in the area of peptide chemistry. Aimed at the research chemist, this book will be enjoyed by the expert while being invaluable to the less experienced. Times Higher Education Supplement 'the book offers a critical and up-to-date account of the chemical principles of peptide synthesis, and by limiting the subject matter it has been kept very compact ... a valuable aid for the newcomer to chemical methods of peptide synthesis ... Its main attraction is that practically every chapter is packed with a wealth of useful detail, a fact that even the specialist will only come to appreciate after studying it closely.' Hans-Dieter Jakubke, Angewandte Chemie, Vol. 31, No. 6, June 1992 'Dr. Jones prepared the text not only in a chronological and scientific style but also with an overview and appreciation of the field with a choice of language and literary skill which makes the text both intellectual and very pleasant to read. This book by Dr. John Jones is highly commendable.' Karl Folkers, The University of Texas at Austin, Journal of the American Chemical Society, Vol. 114, No. 22, 1992 'This book provides a critical, concise, and up-to-date survey of the area.' Evolutionary Aspects . Amino Acids, Peptides & Proteins, Vol. 21, No. 6' `The reprint of this excellent text published in 1991 contains a few corrections and several recent references. The excellent, well-documented selection of material and the lucid, concise, attractive presentation still apply to the reprint. Recommended to those requiring more detail than is available in textbooks of organic chemistry.' Aslib Book Guide, Vol. 50, No. 11, Nov 1994

1. General introduction: Part I. Fundamental Chemical Principles 2: Introduction 3: *a-Amino-protection 4: *a-Carboxy-protection 5: Peptide bond formation 6: Residue specific considerations Part II: The Synthesis of Ordinary Peptides and Proteins 7: Strategy and tactics 8: Solution peptide synthesis 9: Solid phase peptide synthesis 10: Combined approaches and semisynthesis Part III: The Synthesis of Other Peptides 11: Conjugated peptides 12: Simple cyclopeptides 13: More complex modified peptides Epilogue Appendix A. Abbreviations and their uses Appendix B. A select bibliography and literature guide Index

ISBN: 9780198558392
ISBN-10: 0198558392
Series: International Series of Monographs on Chemistry
Audience: Tertiary; University or College
Format: Paperback
Language: English
Number Of Pages: 240
Published: 7th April 1994
Publisher: Oxford University Press
Country of Publication: GB
Dimensions (cm): 23.24 x 15.65  x 1.6
Weight (kg): 0.42