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The Chemical Synthesis of Peptides : INTERNATIONAL SERIES OF MONOGRAPHS ON CHEMISTRY - John Jones

The Chemical Synthesis of Peptides


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Peptides have many roles in medicine, and their potential for future application is even greater. They are involved in the regulation of fertility, the control of pain, the stimulation of growth, cancer therapy, cardiovascular problems, connective tissue diseases, digestive disorders, mental illness, and infections by microbial or viral agents. The preparation of such compounds by manipulating biological systems (genetic engineering) is an increasingly sophisticated art, but each case requires developmental work, and the approach is at present almost powerless with structural types that don't occur naturally. Chemical synthesis, on the other hand, is in principle applicable to any target, and is likely to remain very important in the peptide area for the foreseeable future. The emphasis throughout this book is on the chemical principles behind the more important methods of peptide synthesis. It provides a critical, concise, and up-to-date survey of the field. The term peptide is interpreted liberally, as embracing not only conventional sequences of up to a few dozen natural amino acids, but also protein-scale molecules and structures comprising other residues or unusual features, for example, cyclopeptides and conjugated peptides. The synthetic methods considered here are treated within a modern mechanistic framework, and illustrated with carefully selected case studies, and this valuable account will be of interest to all those working in the field of peptide synthesis.

"An excellent primer." --Choice

"The main advantage of this book over its predecessors is an up-to-date bibliography, which alone may justify its purchase by the novice. The survey is remarkably even-handed and concise, yet entertaining, spiced with personal obtained from the founders of modern peptide synthesis." --Journal of Medicinal Chemistry

"Dr. Jones prepared the text not only in a chronological and scientific style but also with an overview and appreciation of the field with a choice of language and literary skill which makes the text both intellectual and very pleasant to read. . . . highly commendable." --Journal of the American Chemical Society

1. General introduction: Part I. Fundamental Chemical Principles 2: Introduction 3: *a-Amino-protection 4: *a-Carboxy-protection 5: Peptide bond formation 6: Residue specific considerations Part II: The Synthesis of Ordinary Peptides and Proteins 7: Strategy and tactics 8: Solution peptide synthesis 9: Solid phase peptide synthesis 10: Combined approaches and semisynthesis Part III: The Synthesis of Other Peptides 11: Conjugated peptides 12: Simple cyclopeptides 13: More complex modified peptides Epilogue Appendix A. Abbreviations and their uses Appendix B. A select bibliography and literature guide Index

ISBN: 9780198558392
ISBN-10: 0198558392
Audience: General
Format: Paperback
Language: English
Number Of Pages: 240
Published: 1st May 1994
Country of Publication: GB
Dimensions (cm): 23.5 x 15.88  x 1.27
Weight (kg): 0.43

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