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The Challenge of Highly Pathogenic Microorganisms : Mechanisms of Virulence and Novel Medical Countermeasures - Avigdor Shafferman

The Challenge of Highly Pathogenic Microorganisms

Mechanisms of Virulence and Novel Medical Countermeasures

By: Avigdor Shafferman (Editor), Baruch Velan (Editor), Arie Ordentlich (Editor)

Hardcover

Published: 17th June 2010
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The OHOLO conferences are sponsored by the Israel Institute for Biological Research and take their name from the site of the ?rst meeting on the shores of Lake Kinnereth. The purpose of these meetings is, as it was at their inception over 50 years ago, "to foster interdisciplinary communication between scientists in Israel, and to provide added stimulus by the participation of invited scientists from abroad". The core of the organizers of the OHOLO conferences are scientists from the Israel Institute for Biological Research. From time to time a particular OHOLO conference cooperates with an international scienti?c organization. The present 46th OHOLO Conference marks the resumption of the OHOLO tradition after 8 years of interruption caused by events beyond our control. It is my belief that our uncomp- mising commitment to excellence in research and development in the various areas of science in Israel is essential to our survival in this troubled region. The OHOLO conference tradition is a re?ection of this conviction. The present 46th OHOLO Conference entitled: The Challenge of Highly Pathogenic Microorganisms - Mechanisms of Virulence and Novel Medical Countermeasures intends to address the unique virulence features and ho- pathogen interactions of microorganisms constituting emerging biothreat with emphasis on Y. pestis, B. anthracis, F. tularensis and Orthopox viruses. Accordingly we selected classical microbiological as well as genomic, proteomic & transcr- tomic approaches towards developments of novel prophylactic and post-exposure treatment, as well as updated strategies of diagnostics and bioforensics.

The Anthrax Capsule: Role in Pathogenesis and Target for Vaccines and Therapeuticsp. 1
Proteomic Studies of Bacillus anthracis Reveal In Vitro CO2-Modulation and Expression During Infection of Extracellular Proteasesp. 11
Dynamics of Bacillus anthracis Infection and Control Mechanismsp. 23
Survival and Trafficking of Yersinia pestis in Non-acidified Phagosomes in Murine Macrophagesp. 31
The Inverse Relationship Between Cytotoxicity of Y. pestis and Its Virulencep. 45
The NlpD Lipoprotein of Yersinia pestis is Essential for Cell Separation and Virulencep. 57
Dissection of the Functions of the IglC Protein of Francisella tularensisp. 67
Yersinia pestis Lipopolysaccharide in Host-Pathogen Interactionsp. 77
The Interactions Between Pathogens and Dendritic Cells: From Paralysis of Cells to Their Recruitment for Bacterial Colonizationp. 89
Comparative Approaches to Identify Host Factors Specifically Targeted by Yersinia pestis During the Infectious Processp. 99
Poxvirus Entry into Host Cellsp. 107
Role of A33R Amino-Acid 118L in the Interactions of Vaccinia Virus with the Hostp. 115
Inhibitors of Innate Immunity from Vaccinia Virusp. 125
Brucella Species Synchronize Their Life Cycle to the Gestation Cycle of Their Ruminant Hostsp. 135
MMP-9 as a Marker for Vaccinia Virus Related Encephalitisp. 147
Epidemic Cowpox Virus Infections in Germanyp. 157
The Two Partner Secretion Transporters of Yersinia pestis: Cloning, Immunogenicity and In Vivo Expression Following Airway Infectionp. 165
Genetic Detection of Vesicle Forming Pathogens by Arrayed Primer Extension (APEX)p. 173
Subtyping Biothreat Bacterial Pathogensp. 183
A Rapid Method for Bacillus anthracis Genotypingp. 191
Tularemia-A Disease with an Uncertain Impact on Public Healthp. 199
Consequences of Antibiotic Treatment of Francisella tularensis Airways Infectionsp. 207
Novel Live Vaccine Candidates Against Airborne Francisella tularensisp. 213
Effect of Disruption of mglA on the Virulence and Immunogenicity of the Francisella tularensis Live Vaccine Strain (LVS)p. 219
Data Mining, Bioinformatic and Immunoinformatic Analyses of Francisella tularensis Schu S4 Genome in Search for Novel Vaccine Candidatesp. 229
Modified Vaccinia Virus Ankara (MVA) based Vaccines - Immunostimulatory and Protective Capacityp. 245
Therapeutic Potential of Vaccinia Hyper Immune Sera in Mouse Models of Lethal Orthopoxviruses Infectionp. 253
A Live Plaque Vaccine Candidate with Improved Safety and Immunogenecityp. 261
Protection Against Plague Afforded by Treatment with Polyclonal ¿LcrV and ¿F1 Antibodiesp. 269
Combination of Anthrax-Toxin Neutralizing Antibodies: Analysis of Synergism/Antagonism Effectp. 275
The Efficacy of Antibiotic Treatment to Cure Guinea Pigs Intranasally Infected with Bacillus anthracis Sporesp. 287
Reverse Vaccinology in Bacillus anthracisp. 295
Indexp. 307
Table of Contents provided by Ingram. All Rights Reserved.

ISBN: 9789048190539
ISBN-10: 9048190533
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 314
Published: 17th June 2010
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 23.5 x 15.5  x 2.54
Weight (kg): 0.72