The Carbonic Anhydrases

I. The Carbonic Anhydrase Isozymes.- 1. The Carbonic Anhydrases: Overview of Their Importance in Cellular Physiology and in Molecular Genetics.- 2. Structure and Evolutionary Origins of the Carbonic Anhydrase Multigene Family.- 3. X-Ray Crystallographic Studies of Carbonic Anhydrase Isozymes I, II, and III.- 4. Carbonic Anhydrase Kinetics and Molecular Function.- 5. Carbonic Anhydrases in Mammalian Cell Culture and Tumors.- 6. Methods for the Measurement of Carbonic Anhydrase Activity.- II. Carbonic Anhydrase Analysis.- 7. Purification of the Carbonic Anhydrases.- 8. Techniques for Measuring Carbonic Anhydrase Activity in Vitro: The Electrometric Delta pH and pH Stat Methods.- 9. Modified Micromethod for Assay of Carbonic Anhydrase Activity.- 10. Localization of Carbonic Anhydrase by Chemical Reactions.- 11. Localization of the Carbonic Anhydrases by Immunocytochemistry.- 12. Immunological Methods for Detection and Quantification of Carbonic Anhydrase Isozymes.- III. Carbonic Anhydrases in Clinical Medicine.- 13. Carbonic Anhydrase Inhibitors in Ophthalmology.- 14. The Eye: Topical Carbonic Anhydrase Inhibitors.- 15. Carbonic Anhydrase II Deficiency Syndrome: Clinical Delineation, Interpretation, and Implications.- IV. Genetic Regulation of the Carbonic Anhydrase Isozymes.- 16. The Structure and Regulation of the Human Carbonic Anhydrase I Gene.- 17. Expression of Carbonic Anhydrases I and II in Mouse Erythropoiesis.- 18. Structure and Expression of the Carbonic Anhydrase III Gene.- V. Muscle Carbonic Anhydrases.- 19. Muscle Carbonic Anhydrases: Function in Muscle Contraction and in the Homeostasis of Muscle pH and pCO2.- 20. Distribution and Ultrastructural Localization of Carbonic Anhydrase III in Different Skeletal Muscle Fiber Types.- 21. Hormonal and Neuronal Control of Carbonic Anhydrase III Gene Expression in Skeletal Muscle.- 22. Skeletal Muscle Mitochondrial Carbonic Anhydrase: A Case of Species Specificity.- VI. Carbonic Anhydrases of the Gastrointestinal Tract.- 23. Distribution and Functions of Carbonic Anhydrase in the Gastrointestinal Tract.- 24. Hormonal Regulation and Localization of Rat Liver Carbonic Anhydrase.- 25. Liver Mitochondrial Carbonic Anhydrase (CA V), Gluconeogenesis, and Ureagenesis in the Hepatocyte.- VII. The Carbonic Anhydrases of Other Organs.- 26. Function and Regulation of the Carbonic Anhydrases in the Vertebrate Neural Retina.- 27. Carbonic Anhydrase and Sensory Function in the Central Nervous System.- 28. Carbonic Anhydrase in Myelin and Glial Cells in the Mammalian Central Nervous System.- 29. Lung Carbonic Anhydrase.- 30. Carbonic Anhydrase and Chemoreception in Carotid and Aortic Bodies.- 31. Carbonic Anhydrases in the Kidney.- 32. Localization of Carbonic Anhydrase Isozymes in Calcified Tissues.- 33. Carbonic Anhydrase and Skeletogenesis.- 34. Carbonic Anhydrases Secreted in the Saliva.