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The Carbonic Anhydrases : New Horizons :  New Horizons - W. R. Chegwidden

The Carbonic Anhydrases : New Horizons

New Horizons

By: W. R. Chegwidden (Editor), N. D. Carter (Editor), Y. H. Edwards (Editor)

Hardcover Published: November 2000
ISBN: 9783764356705
Number Of Pages: 619

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Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis, bone resorption, calcification, photosynthesis, several biosynthetic pathways and a variety of processes involving ion, gas and fluid transfer. This enzyme, which is present in at least three gene families (a, ß, ?), has found favour as a model for the study of evolution of gene families and for site-directed mutagenesis in structure/function relationships, for protein folding and for transgenic and gene target studies. Since the early use of CA inhibitors as diuretics and in treating congestive heart failure, the enzyme has been target of considerable clinical attention. Much of this is now focused on endeavours to produce a new generation of such drugs for the effective treatment of glaucoma and other potential applications. Recent data, suggesting links between CA and various disease processes, including cancer, have stimulated further...

List of Contributors
Dedications
Preface
Exordium: Remarks on the discovery of carbonic anhydrasep. 1
Introduction to the carbonic anhydrasesp. 13
Evolution and distribution of the carbonic anhydrase gene familiesp. 29
An overview of the distribution and function of carbonic anhydrase isozymes in mammalsp. 79
The membrane carbonic anhydrases: from CO[subscript 2] transport to tumour markersp. 95
Carbonic anhydrase (CA)-related proteins (CA-RPs), and transmembrance proteins with CA or CA-RP domainsp. 105
Regulation of the CA 1, CA and CA 3 genesp. 121
Use of carbonic anhydrase II-deficient mice in uncovering the cellular location of membrane-associated isoformsp. 143
X-ray crystallographic studies of mammalian carbonic anhydrase isozymesp. 159
The catalytic mechanism of mammalian carbonic anhydrasesp. 175
Activation of carbonic anhydrase isozymesp. 197
Active-site engineering of carbonic anhydrase and its application to biosensorsp. 221
Folding and stability of human carbonic anhydrase IIp. 241
Membrane transport and provision of substrates for carbonic anhydrase in vertebratesp. 263
Respiratory and renal roles of carbonic anhydrase in gas exchange and acid-base regulationp. 281
The roles of carbonic anhydrase in metabolism, cell growth and cancer in animalsp. 343
The roles of carbonic anhydrase in gustation, olefaction and chemical irritationp. 365
Carbonic anhydrases in striated nmusclep. 375
Inherited deficiencies and activity variants of the mammalian carbonic anhydrasesp. 403
Carbonic anhydrase inhibition in ophthalmology: Carbonic anhydrase in cornea, lens, retina and lacrimal glandp. 413
Carbonic anhydrase inhibition in ophthalmology: Aqueous humour secretion and development of sulphonamide inhibitorsp. 425
The design of new carbonic anhydrase inhibitorsp. 437
Roles of carbonic anhydrases in the alimentary tractp. 461
Carbonic anhydrases in the nervous systemp. 475
Carbonic anhydrases in calcified tissuesp. 491
Carbonic anhydrases of higher plants: an overviewp. 501
Plant carbonic anhydrases: structure and mechanismp. 519
Algal carbonic anhydrasep. 535
Bacterial carbonic anhydrasesp. 547
Keeping pace with a fast enzyme: steps and misstepsp. 569
Carbonic anhydrase research: A clinical perspective, past and futurep. 597
Indexp. 611
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9783764356705
ISBN-10: 3764356707
Series: Experientia Supplementum
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 619
Published: November 2000
Publisher: SPRINGER VERLAG GMBH
Country of Publication: CH
Dimensions (cm): 23.39 x 15.6  x 3.51
Weight (kg): 1.07

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