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The Biological Chemistry of the Elements : The Inorganic Chemistry of Life - J. J. R. Frausto da Silva

The Biological Chemistry of the Elements

The Inorganic Chemistry of Life

Paperback Published: 1st September 2001
ISBN: 9780198508489
Number Of Pages: 600

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Twenty inorganic elements, mostly metal ions, are consistently found in living systems and are essential for living systems to function correctly. The aim of this text is to discuss, describe, and explain the functional relevance of those elements: the reasons for their selection; the processes of their uptake, transport and final localization in cells; the regulation of these processes; and the interactive network of their reactions that connects the in vivo inorganic elements to the environment and to the genome. The first seven chapters describe the physical, chemical, and biological principles of the involvement of the elements in cellular activity, stressing how inorganic and organic chemicals react differently together in different compartments. The next twelve chapters describe the uses of the individual essential inorganic elements and a section on the genetic control of each element is included. The final chapter discusses how the interaction of genes, proteins, small molecules, and inorganic elements plays an important role in evolution and the speciation of organisms. The second edition of 'The Biological Chemistry of The Elements' has been thoroughly revised in content and style. The main additions to the first edition concern the discussion of the links to the genome of the uptake and transfer of inorganic elements and the regulation of homeostasis, the functional co-operative activities of the elements, the interaction with the environment, and the evolution of usage. Recent structural and mechanistic knowledge of many biomolecules and organelles are also included. Like the higly praised first edition, this text will be the bible of bioinorganic chemistry.

Review from previous edition "Rich and refreshing...in addition to being a general resource, this engaging book provides an excellent text for an advanced course and should have much to teach both students and teachers." Nature " Because Williams's numerous publications cut a wide swath, it is useful to have this book where his breadth of knowledge, viewpoints and insights reside conveniently in one place ... this engaging book provides an excellent text for an advanced course and should have much to teach both students and teachers." Nature "This account is no mere review or compendium but an original and imaginative synthesis of its subject matter. Its powerful insights will change the way the subject develops, if only because the authors sometimes run ahead of our ability to give a complete or detailed description of a given system. In short it sets a chemical framework within which biology and its evolution can be understood and interpreted." Journal of Bioinorganic Chemistry "I recommend this book to all biologists and I am certain that it will prove something of a literary landmark in its contribution to the understanding of biology in the future."R TIBS "Destined to become the bible of bio-inorganic chemistry. The Biological Chemistry of the Elements is a superb book" Times Higher Education Supplement "This is a comprehensive treatment of the role of the chemical elements ... The book will be of interest to both chemists and biologists and students of biochemistry would certainly benefit from reading it."R ASLIB Book Guide "outstanding book ... The contents are well ordered and liberally subtitled and there are many excellent tables and figures, which are all helpful to the reader. I recommend this book to all biologists and I am certain that it will prove something of a literary landmark in its contribution to the understanding of biology in the future." TIBS "stimulating book" Biologist "It is a remarkable book in range and bioinorganic vision. Each section is well referenced with further reading, required for rounding-out the global perspectives presented." Chemistry and Industry "This book presents a novel approach to the subject of biochemistry, which is both interesting and fascinating ... practicing scientists from either biochemistry or inorganic chemistry would find this book a valuable source for relevant information regarding the impact of the other discipline on their own ... For a person working at the interface of inorganic chemistry and biochemistry this book will be extremely valuable. For others it will be an excellent reference to have at hand. The book is well written and understandable." Journal of Chemical Education "The text is arranged in short sections with headings that stand out clearly, and a liberal use is made of space, all of which makes for excellent clarity. "The Biological Chemistry of the Elements" is an attractive book and is a pleasure to read." Angewandte Chemie " The importance of these essential elements is explained in a fresh and original manner in 'The Biological Chemistry of the Elements ... for the advanced student it makes invigorating reading." New Scientist "It covers a subject which is of immense importance and current interest ... It is very well produced, with excellent illustrations and bibliography. Each chapter in itself provides a great deal of information." Biomaterials "The book combines the features of an advanced text and a monograph and has an aesthetically attractive outlook" Structural Chemistry

The chemical and physical factors controlling the elements of life1: The chemical elements in biology 2: The principles of the uptake and chemical speciation of the elements in biology 3: Physical separations of elements: compartments and zones in biology 4: Kinetic considerations of chemical reactions, catalysis, and control 5: Energy in biological systems and hydrogen biochemistry 6: The role of biological macromolecules and polymers 7: The functional value of the chemical elements in biological systems The roles of individual elements in biology8: Sodium, potassium, and chlorine: osmotic control, electrolytic equilibria, and currents 9: The biological chemistry of magnesium: phosphate metabolism 10: Calcium: controls and triggers 11: Zinc: Lewis acid catalysis and regulation 12: Non-haem iron: redox reactions and controls 13: Haen iron: coupled redox reactions 14: Manganese: dioxygen evolution and glycosylation 15: Copper: extracytoplasmic oxidases and matrix formation 16: Nickel and cobalt: remnants of early life 17: Molybdenum, tungsten, vanadium, and chromium 18: Phosphate, silica, and chloride: acid-base non-metals 19: Sulphur, selenium, and the halogens: redox non-metals 20: Integrated living systems of elements

ISBN: 9780198508489
ISBN-10: 0198508484
Audience: Professional
Format: Paperback
Language: English
Number Of Pages: 600
Published: 1st September 2001
Publisher: Oxford University Press
Country of Publication: GB
Dimensions (cm): 24.7 x 18.9  x 3.2
Weight (kg): 1.33
Edition Number: 2
Edition Type: Revised