Technological and Medical Implications of Metabolic Control Analysis

By: Athel Cornish-Bowden (Editor), Maria Luz Cárdenas (Editor)

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Paperback | 29 February 2000

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392 Pages

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Two decades have passed since the mechanisms of protein synthesis became well enough understood to permit the genetic modification oforganisms. An impressive amount of new knowledge has emerged from the new technology, but much ofthe promise of20years ago has notyet been fulfilled. In biotechnology, efforts to increase the yields of commercially valuable metabolites have been less successful than ex pected, and when they have succeeded it has often been as much from selective breeding as from new methods. The cell is more complicated than what is presented in the classical teaching of biochemistry, it contains more structure than was dreamed of 20 years ago, and the behaviour ofany systemofenzymes is more elaborate than can be explained in terms ofa single supposedly rate-limiting enzyme. Even if classical enzymology and meta bolism may have seemed rather unfashionable during the rise ofmolecular biology, they remain central to any modification ofthe metabolic behaviour oforganisms. As such modification is essential in much ofbiotechnology and drug development, bio technologists can only ignore these topics at their peril.

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You Can Find This Book In

Non-Fiction Medicine Clinical & Internal Medicine Endocrinology Pre-Clinical Medicine & Basic Sciences Physiology Metabolism Engineering & Technology Biochemical Engineering Biotechnology Diseases & Disorders Immunology

Allergies Science Biology, Life Sciences Biochemistry Mathematics Applied Mathematics Oncology

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Published: 29th February 2000

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Preface
Provoking an Argument: Problems with Current Approaches to the Analysis of Biochemical Systems
Imposing Discipline: Manipulation of Organisms for Technological Ends
Understanding Health and Disease: Why Organisms Behave as they do
Taking Aim: Use of Metabolic Models to identify Drug Targets
Facing Reality: Not just a Bag of Enzymes
Thinking about Metabolism: The Relationship Between Control and Regulation
Taking Stock: Control Analysis in the Context of Metabolic Regulation
Contributors
Index
Table of Contents provided by Publisher. All Rights Reserved.

Technological and Medical Implications of Metabolic Control Analysis

At a Glance

Paperback

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How to return your order

Defective items

You Can Find This Book In

Other Editions and Formats

Hardcover

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