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Tachykinins : Handbook of Experimental Pharmacology - Peter Holzer


Handbook of Experimental Pharmacology

By: Peter Holzer (Editor)

Hardcover Published: 1st August 2004
ISBN: 9783540206903
Number Of Pages: 569

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More than 70 years have elapsed since U. S. von Euler and I. H. Gaddum dis­ covered an unidentified depressor substance in the brain and gut. The effects of the powdery extracts were marked as 'P' on the kymograph tracings, and the nondescript name of 'substance P' still carries the breath of this adventurous period. In the 1960s, substance P returned in another disguise, staging as a hypothalamic peptide that causes copious salivary secretion (see chapter by F. Lembeck and I. Donnerer). This time, though, the mysterious substance was tracked down by S. E. Leeman and her collaborators as an undecapeptide, after it had eluded its identification for some 40 years. Substance P turned out to be the mammalian counterpart of a family of peptides which had been extracted from amphibian and nonvertebrate species and which had been given the name 'tachykinins' by V. Erspamer. Soon novel members of this peptide family were discovered, and in mammals substance P was joined by neurokinin A and neu­ rokinin B. The presence of tachykinins in frog skin as well as in venoms and toxins of microbes and arachnids raises the possibility that these peptides re­ present an old system of biological weapons that have been transformed to a particular messenger system in mammals.

History of a pioneering neuropeptide : substance Pp. 1
The tachykinin peptide family, with particular emphasis on mammalian tachykinins and tachykinin receptor agonistsp. 25
The histochemistry of tachykinin systems in the brainp. 63
The nomenclature of tachykinin receptorsp. 121
The mechanism and function of agonist-induced trafficking of tachykinin receptorsp. 141
Tachykinin NK[subscript 1] receptor antagonistsp. 173
Tachykinin NK[subscript 2] receptor antagonistsp. 219
Tachykinin NK[subscript 3] receptor antagonistsp. 245
Combined tachykinin NK[subscript 1], NK[subscript 2], and NK[subscript 3] receptor antagonistsp. 273
Pre-protachykinin and tachykinin receptor knockout micep. 297
Therapeutic potential of tachykinin receptor antagonists in depression and anxiety disordersp. 341
The role of tachykinins and the tachykinin NK[subscript 1] receptor in Nausea and Emesisp. 359
Substance P (NK[subscript 1]) receptor antagonists - analgesics or not?p. 441
Role of tachykinins in neurogenic inflammation of the skin and other external surfacesp. 459
Role of tachykinins in obstructive airway diseasep. 491
Role of tachykinins in the gastrointestinal tractp. 511
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9783540206903
ISBN-10: 3540206906
Series: Handbook of Experimental Pharmacology
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 569
Published: 1st August 2004
Country of Publication: DE
Dimensions (cm): 23.39 x 15.6  x 3.18
Weight (kg): 0.99

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