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Synthetic Glycomes : Chemical Biology - Peng George Wang

Synthetic Glycomes

Chemical Biology

By: Peng George Wang (Editor), Wanyi Guan (Editor), Lei Li (Editor)

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Glycans play essential roles in diverse biological and etiological processes and their structural complexity endow various functions. The glycome is the entire set of glycans produced by an individual organism. As the glycan microarray emerged, a good amount of knowledge has been obtained in understanding the functions of glycans. However, limited accessibility of glycans is a major obstacle to the functional glycomics study. Although isolation from biology samples provided some structures, the low abundance of glycans obtained and the difficulty in complete structural assignment restricted the subsequent assay. To circumvent this limitation, many synthetic strategies, including chemical, enzymatic and chemo-enzymatic ones have been developed to make libraries of structurally defined complex glycans available. The glycans provided by these techniques combined with high-throughput glycoarray techniques have broadened and deepened our understanding about functional glycomics. The aim of this book is to provide a comprehensive review of the current state of the synthetic glycome and a brief introduction of the application of the synthetic glycome in glycoarray assay. Accordingly, synthetic strategies toward generating glycans with comprehensive structures as well as the glycoarrays to unveil the glycan functions are described in this book.

ISBN: 9781788011648
ISBN-10: 1788011643
Series: Chemical Biology
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 469
Published: 29th April 2019
Country of Publication: GB
Dimensions (cm): 23.37 x 16.51  x 3.3
Weight (kg): 0.86