Synthesis of Carbohydrates Through Biotechnology discusses the engineering of glycosyltransferases and carbohydrate-active enzymes for preparative purposes, structure-function studies, chemo-enzymatic carbohydrate synthesis, and new approaches on carbohydrate-based drug discoveries. Practitioners in the carbohydrate and genetic engineering fields, especially those in the medicinal, chemical, and pharmaceutical areas, will find this book useful.
Carbohydrates and their conjugates occur in biological and immunological processes such as molecular recognition and host-pathogen interactions. Carbohydrate structures also frequently change upon carcinogenic transformation. Glycomics, which is the study of an organism's entire array of oligosaccharides, is now emerging as the third informatics wave after genomics and proteomics. This major area will help us understand the molecular phenotype. Because of the complexities of carbohydrates, the function of the majority of carbohydrates in biological systems still needs to be explored.
Although carbohydrates are less interesting targets for drug development, they are important components in many valuable therapeutics such antibiotics and anticancer agents. For these reasons, more reliable technologies to efficiently assemble glycoconjugates are absolutely needed to enable their studies.
1: Przemyslaw Kowal, Jun Shao, Mie Li, Wen Yi, Hanfen Li, and Peng George Wang: Approaches to the Enzymatic Carbohydrate Synthesis
2: Obadiah J. Plante: Exploring Carbohydrate Diversity through Automated Synthesis
3: Shirley A. Wacowich-Sgarbi, David Rabuka, Paulo W.M. Sgarbi, and Yoshi Ichikawa: Glycosynthesis for Drug Discovery:Globo H Synthesis by OPopS
4: Ruby Wang, Brian J. Trummer, Ellen Gluzman, Chao Deng, and Denong Wang: Probing the Antigenic Diversity of Sugar Chains
5: Fengyang Yan, Seema Mehta, Eva Eichler, Warren Wakarchuk, and Dennis M. Whitfield: Chemoenzymatic Synthesis of Lactosamine and (a2-3) Sialylated Lactosamine Building Blocks
6: Lai-Xi Wang, Suddham Singh, and Jiahong Ni: Synthesis of Bioactive Glycopeptides through Endoglycosidase-Catalyzed Transglycosylation
7: Ola Blixt and Nahid Razi: Strategies for Synthesis of an Oligosaccharide Library Using a Chemoenzymatic Approach
8: Shin-Ichiro Nishimura, Noriko Nagahori, Reiko Sadamoto, Kenji Monde, and Kenichi Nikura: Artificial Golgi Apparatus: Direct Monitoring of Glycosylation Reactions on Automated Glycosynthesizer
9: Paul L. DeAngelis: Sugar Engineering with Glycosaminoglycan Synthases
10: Laure Jolly, Veronique Tornare, and Sunil Kochhar: Production of Oligosaccharides Using Engineered Bacteria: Engineering of Exopolysaccharides from Lactic Acid Bacteria
11: Satoshi Koizumi: Production of Oligosaccharides by Coupling Engineered Bacteria
12: Mei Li, Jun Shao, Min Xiao, and Peng George Wang: Synthesis of Glycoconjugates through Biosynthesis Pathway Engineering
Series: ACS Symposium Series
Number Of Pages: 208
Published: 28th February 2004
Publisher: Oxford University Press Inc
Country of Publication: US
Dimensions (cm): 23.7 x 16.0
Weight (kg): 0.38