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Synaptic Plasticity and the Mechanism of Alzheimer's Disease : Research and Perspectives in Alzheimer's Disease - Dennis J. Selkoe

Synaptic Plasticity and the Mechanism of Alzheimer's Disease

Research and Perspectives in Alzheimer's Disease

By: Dennis J. Selkoe (Editor), Antoine Triller (Editor)

Hardcover Published: 21st March 2008
ISBN: 9783540763291
Number Of Pages: 183

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A biochemical hypothesis - that Alzheimer's disease (AD) is a progressive cerebral amyloidosis caused by the aggregation of the amyloid b-protein (Ab) - preceded and enabled the discovery of etiologies. This volume serves as a record focused on bringing together investigators at the forefront of elucidating the structure and function of hippocampal synapses with investigators focused on understanding how early assemblies of Ab may compromise some of these synapses.

Permanence of the Synapse and Molecular Instabilityp. 1
Cellular Biology of AMPA Receptor Trafficking and Synaptic Plasticityp. 19
Imaging of Experience-Dependent Structural Plasticity in the Mouse Neocortex in vivop. 37
Synapse Loss, Synaptic Plasticity and the Postsynaptic Densityp. 51
Impact of Beta Amyloid on Excitatory Synaptic Transmission and Plasticityp. 63
Quantitative Neuropathology in Alzheimer's Mouse Modelsp. 69
Multiple Levels of Synaptic Regulation by NMDA-type Glutamate Receptor in Normal and Disease Statesp. 75
Soluble Oligomers of the Amyloid &gb-Protein: Impair Synaptic Plasticity and Behaviorp. 89
Why Alzheimer's is a Disease of Memory: Synaptic Targeting by Pathogenic A[beta] Oligomers (ADDLs)p. 103
Synaptic Transmission Dynamically Modulates Interstitial Fluid Amyloid-[beta] Levelsp. 133
A[beta]-Induced Toxicity Mediated by Caspase Cleavage of the Amyloid Precursor Protein (APP)p. 145
Long-Term Potentiation and A[beta]: Targeting A[beta] Species, Cellular Mechanisms and Putative Receptorsp. 157
Genes, Synapses and Autism Spectrum Disordersp. 169
Subject Indexp. 181
Table of Contents provided by Ingram. All Rights Reserved.

ISBN: 9783540763291
ISBN-10: 3540763295
Series: Research and Perspectives in Alzheimer's Disease
Audience: Tertiary; University or College
Format: Hardcover
Language: English
Number Of Pages: 183
Published: 21st March 2008
Publisher: Springer-Verlag Berlin and Heidelberg Gmbh & Co. Kg
Country of Publication: DE
Dimensions (cm): 23.5 x 15.5  x 1.27
Weight (kg): 0.46