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Supramolecular Chemistry : From Biological Inspiration to Biomedical Applications - Peter J. Cragg

Supramolecular Chemistry

From Biological Inspiration to Biomedical Applications

Hardcover

Published: 6th September 2010
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The aim of this book is to return to the biomimicry and medicinal potential that inspired many of the early supramolecular chemists and to set it in the context of current advances in the field.

Following an overview of supramolecular chemistry, the first section considers the efforts made to synthesize artificial systems that mimic biological entities. The second section addresses the application of supramolecular principles to molecular diagnostics with a particular emphasis on the `receptor-relayreporter' motif. Many of the examples chosen have clinical importance. The third section takes the clinical diagnostic theme further and demonstrates the therapeutic applications of supramolecular chemistry through photodynamic therapy, drug delivery, and the potential for synthetic peptides to form antibiotic tubes. The short epilogue considers the potential for supramolecular solutions to be found for further challenges in biomimetic and therapeutic chemistry.

An Introduction to Supramolecular Chemistryp. 1
Supramolecular Chemistryp. 1
Originsp. 3
Supramolecular Chemistry and Nanotechnologyp. 5
Fundamental Supramolecular Interactionsp. 8
Covalent Bondsp. 9
Reversible Covalent Bondsp. 9
Ionic Interactionsp. 11
Ion-Dipole Interactionsp. 11
Dipole-Dipole Interactionsp. 12
Hydrogen Bondsp. 12
Cation-¿ Interactionsp. 13
¿-¿ Interactionsp. 13
van der Waals Forcesp. 13
Hydrophobie Effectsp. 13
Supramolecular Componentsp. 14
Supramolecular Complexes from Simple Ligandsp. 14
Macrocyclesp. 19
Supramolecular Entanglementsp. 30
Catenanes and Rotaxanesp. 30
Gridsp. 37
Dynamic Combinatorial Librariesp. 37
Observing Supramoleculesp. 39
Isolationp. 39
Detectionp. 39
Summaryp. 44
Referencesp. 44
Supramolecular Chemistry and the Life Sciencesp. 49
Life as a Supramolecular Phenomenonp. 49
Supramolecular Interactions in Biological Systemsp. 50
Amino Acidsp. 50
Proteinsp. 54
Sugarsp. 57
Glycoproteinsp. 58
Lipidsp. 59
RNA and DNAp. 60
Unusual Structural Forms of DNAp. 64
Self-Replication as the Key to Lirep. 66
Replicatorsp. 66
Replicator Evolutionp. 68
Orthogonal Translationp. 69
Supramolecular Self-Replicationp. 71
Self-Assembling and Self-Replicating Motifsp. 73
Supramolecular Chemistry and the Origin of Lifep. 79
Compartmentalization: The Lipid Worldp. 80
Catalysis: The Iron-Sulfur Worldp. 83
Self-Replication: The RNA Worldp. 83
Supramolecular Biology and Synthetic Biologyp. 86
Summaryp. 87
Referencesp. 87
Artificial Cellsp. 91
Cells as Capsulesp. 91
Natural Capsulesp. 91
Clathrinsp. 92
Viral Capsidsp. 93
Coat Proteinsp. 94
Vault Proteinsp. 94
Unnatural Capsulesp. 95
Self-Complementary Capsulesp. 96
Boxes with Metal Hingesp. 97
Capsules as Reaction Flasksp. 100
More Complex Geometriesp. 101
Synthetic Cellsp. 102
Capsules with Mineral Wallsp. 102
Polymer Based Capsulesp. 104
Lipid Capsulesp. 105
Capsid Virus Mimeticsp. 107
Towards a Minimal Synthetic Cellp. 107
Cellular Aggregationp. 109
Summaryp. 110
Referencesp. 110
Supramolecular Enzyme Mimicsp. 113
Enzymesp. 113
Metal Complexes as Enzyme Mimicsp. 116
Enzymes and Their Supramolecular Analoguesp. 118
Haemoglobin, Myoglobin and Their Modelsp. 119
Cytochromesp. 121
Protection from Radicals: Catalytic Pro- and Antioxidantsp. 122
Copper-Containing Enzymesp. 127
Zinc-Containing Enzymesp. 132
Photosynthesis and Artificial Leavesp. 136
Cyclodextrins as Artificial Enzyme Supportsp. 142
Model Enzymes that do not Require Metalsp. 143
Molecularly Imprinted Polymersp. 144
Combinatorial Polymersp. 144
Dynamic Combinatorial Librariesp. 145
De novo Design and Evolutionary Development of Enzymesp. 146
Summaryp. 148
Referencesp. 148
Natural and Synthetic Transmembrane Channelsp. 153
Cells and Their Membranesp. 153
Cell Membranesp. 153
Transmembrane Migration: Molecular Shuttlesp. 155
Transmembrane Channels: Selectivity and Gating Mechanismsp. 157
Voltage Gatingp. 158
Ligand Gatingp. 158
Gating by Aggregationp. 158
Gating by pH and Membrane Tensionp. 159
Light Gatingp. 160
Channel Architecturep. 161
Channels for Neutral Moleculesp. 162
Anion Channelsp. 163
Cation Channelsp. 163
Structural Determinationp. 167
Measuring Channel Activityp. 169
Voltage Clampingp. 169
Patch Clampingp. 169
Bilayer Methodsp. 170
Dye Release Methodsp. 170
NMR Methodsp. 170
Transmembrane Transport by Artificial Systemsp. 171
Transportersp. 171
Channel-Forming Systemsp. 172
Summaryp. 180
Referencesp. 181
Diagnostic Applicationsp. 185
Applications of Supramolecular Chemistry in Medical Diagnosticsp. 185
Design Principlesp. 185
Supramolecular Sensorsp. 188
Optical and Fluorescent Biosensorsp. 188
Electrochemical Sensorsp. 195
Macrocyclic Complexes for Imagingp. 197
In vivo Imaging: Magnetic Resonance Imaging Agentsp. 199
Other Supramolecular Sensorsp. 203
Summaryp. 204
Referencesp. 204
Supramolecular Therapeuticsp. 207
Therapeutic Applications of Supramolecular Chemistryp. 207
Chelation Therapyp. 208
Desferoxaminep. 209
Copper Imbalance: Wilson's Disease and Menke's Syndromep. 210
Macrocyclic Complexes for Radiotherapyp. 211
Photodynamic Therapyp. 211
Texaphyrinsp. 214
Targeting Cancer with Peptidesp. 216
Drug Delivery and Controlled Releasep. 216
Cyclams as Anti-HIV Agentsp. 217
A Supramolecular Solution to Alzheimer's Disease?p. 219
Calixarenes as Therapeutic Agentsp. 222
Supramolecular Antibioticsp. 224
Summaryp. 227
Referencesp. 228
Bionanotechnology, Nanomedicine and the Futurep. 231
Bionanotechnologyp. 231
The Unnatural Chemistry of DNAp. 232
Molecular Musclesp. 235
Nanomedicinep. 238
Labelling with Nanoparticlesp. 239
DNA Fingerprintingp. 240
Full Genome Sequencingp. 240
DNA Sequencing in Real Timep. 242
Therapeutic Multimodal Nanoparticlesp. 244
Cell Mimics as Drug Delivery Vehiclesp. 246
Polymer Encapsulated siRNA Deliveryp. 246
Drug Delivery by Particle Disintegrationp. 247
Minicells as Drug Delivery Systemsp. 248
Supramolecular Protein Engineeringp. 249
Antimicrobial Limpet Minesp. 249
Future Directionsp. 251
Medicinal Nanodevicesp. 251
Powering Nanodevicesp. 252
Functional Nanodevicesp. 252
Verification of Treatmentp. 253
Nanodevice Controlp. 254
Supramolecular Chemistry and Nanomedicinep. 254
Referencesp. 254
Indexp. 257
Table of Contents provided by Ingram. All Rights Reserved.

ISBN: 9789048125814
ISBN-10: 9048125812
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 260
Published: 6th September 2010
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 23.5 x 15.5  x 1.91
Weight (kg): 0.63