Subcellular Basis of Contractile Failure

I. Role of Cations in Heart Function.- 1. Role for sodium channels and intracellular sodium in regulation of the cardiac force-frequency relation and contractility.- 2. Regulation of cardiac calcium current during suppression of second messenger intracellular enzymatic pathways.- 3. Hormonal and non-hormonal regulation of Ca2+ current and adenylate cyclase in cardiac cells.- 4. Calcium current in normal and hypertrophied isolated rat ventricular myocytes.- 5. Regulation of contractile activity in single adult cardiomyocytes isolated from four different species: The effect of reduced sodium gradient.- 6. Involvement of sodium-calcium exchange in cardiac pathology.- 7. Modifications in sarcolemmal regulation of Ca2+ with aging.- II. Cardiac Hypertrophy and Cardiomyopathies.- 8. Alterations of membrane proteins in cardiac hypertrophy.- 9. Signal transduction in myocardial hypertrophy and myosin expression.- 10. Molecular and subcellular mechanisms of thyroid hormone induced cardiac alterations.- 11. Membrane abnormalities and changes in cardiac cations due to alterations in thyroid status.- 12. Inhibitory effects of captopril on the onset of cardiomyopathy in cardiomyopathic hamsters.- 13. Altered myocardial contractility and energetics in renovascular hypertensive rats.- 14. Cardiac phosphatidylethanolamine N-methylation in normal and diabetic rats treated with L-propionylcarnitine.- III. Ischemic Heart Disease and Cardiac Failure.- 15. Dietary N-3 polyunsaturated fatty acids and ischemic heart disease.- 16. Role of free radicals in the development of ischemic heart disease.- 17. Cardiovascular membranes as models for the study of free radical injury.- 18. Oxidation of myofibrillar thiols: A mechanism of contractile dysfunction reversible by dithiothreitol.- 19. Cardiac contractile failure due to oxygen radicals in an ex vivo system.- 20. Subcellular basis of contractile failure in myocytes: Calcium overload or energy depletion?.