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Structural Biology and Functional Genomics : NATO Science Partnership Subseries: 3 - Morton Bradbury

Structural Biology and Functional Genomics

NATO Science Partnership Subseries: 3

By: Morton Bradbury (Editor), Sandor Pongor (Editor)

Paperback

Published: 1st August 1999
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Biomedical research will be revolutionised by the current efforts to sequence the human genome and the genomes of model organisms. Of the newly sequenced genes, 50% code for proteins of unknown functions, while as little as 5% of sequences in mammalian genomes code for proteins. New, genome-wide approaches are needed to draw together the knowledge that is emerging simultaneously in a number of fields of genome research.
This volume is a high-level survey of the newly emerging concepts of structural biology and functional genomics for biologists, biochemists and medical researchers interested in genome research. Topics included are chromosome and chromatin organisation, novel DNA and RNA structures, DNA flexibility, supercoiling, prediction of protein functions, strategies for large scale structural analysis, and computer modelling.

Preface
Acknowledgements
The Skeletal Function of Non-Genic Nuclear DNA: New Evidence from Ancient Cell Chimaeras
DNA Repeats in the Human Genome
Left-Handed Z-DNA: Structure and Function
Superhelical DNA Studied by Solution Scattering and Computer Models
Micro-Mechanical Measurement of the Torsional Modulus of DNA
Sequence-Dependent Modelling of Local DNA Bending Phenomena: Curvature Prediction and Vibrational Analysis
Modelling DNA Stretching for Physics and Biology
Single-Chain 434 Repressors With Altered DNA-Binding Specificities: Isolation of Mutant Single-Chain Repressors by Phenotypic Screening of Combinatorial Mutant Libraries
Fast Combinatorial Cartography by Fish on Combed Genomic DNA
RNA Folding and Catalysis
Histone-DNA Contacts in Structure/Function Relationships of Nucleosomes as Revealed by Crosslinking
The Role of Histone H1 in Chromatin Condensation and Transcriptional Repression
Chromatin Control of HIV-1 Gene Expression
Mechanisms of Separation of the Complementary Strands of DNA During Replication
Exploring Structure Space: A Protein Structure Initiative
The Protein Data Bank: Bridging the Gap between the Sequence and 3D Structure World
Functional Genomics and Enzyme Evolution: Homologous and Analogous Enzymes Encoded in Microbial Genomes
The Beamlines of Elettra and Their Application to Structural Biology
Subject Index
Participants List
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780792357827
ISBN-10: 0792357825
Series: NATO Science Partnership Subseries: 3
Audience: General
Format: Paperback
Language: English
Number Of Pages: 313
Published: 1st August 1999
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 22.86 x 15.88  x 1.91
Weight (kg): 0.5