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Structural and Biochemical Characterization of the Yaxab Pore-Forming Toxin from Yersinia Enterocolitica : Springer Theses - Bastian Brauning

Structural and Biochemical Characterization of the Yaxab Pore-Forming Toxin from Yersinia Enterocolitica

Springer Theses

Hardcover Published: 9th October 2019
ISBN: 9783030294380
Number Of Pages: 86

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This book discusses the decoding of the lytic mechanism of an α-helical pore-forming toxin, YaxAB, composed of two different subunits. Pore-forming toxins (PFTs) are among the most common bacterial toxins. They are produced by a variety of pathogens, which infect a wide range of organisms including plants, insects and humans. Yet the maturation of these particles and the structural changes required for pore formation are still poorly understood for many PFT families. Using a diverse panel of biochemical and structural techniques, including X-ray crystallography and cryo-electron microscopy, Dr. Br uning and colleagues have succeeded in identifying the mechanistic contributions of the two toxin components and elucidating the lytic state of the pore complex. The results of this thesis on the YaxAB system are applicable to orthologues from agriculturally relevant insect pathogens, and offer valuable structural and mechanistic insights to inform future bioengineering efforts.

ISBN: 9783030294380
ISBN-10: 3030294382
Series: Springer Theses
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 86
Published: 9th October 2019
Publisher: SPRINGER VERLAG GMBH
Country of Publication: CH
Dimensions (cm): 23.39 x 15.6  x 0.79
Weight (kg): 0.35

Earn 456 Qantas Points
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