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Stroke Genomics : Methods and Reviews - Simon J. Read

Stroke Genomics

Methods and Reviews

By: Simon J. Read (Editor), David Virley (Editor)


Published: 21st September 2004
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Leading experts explore the pragmatic application of the tools of genomic and molecular biology research to the treatment of stroke. Providing the reader with cutting-edge reviews of clinical and preclinical genomics, the authors relate changes ingene expression to physiological endpoints - such as functional imaging paradigms - to produce a more holistic approach in which molecular biology goes hand-in-hand with stroke pathophysiology. Topics of special interest include stem cell transplantation, gene therapy, clinical gene/gene interaction studies, and cytokine drug discovery. Readily reproducible techniques are provided, along with ancillary methods (imaging, animal models, human genetic study design, and transgenic animal production) that can be effectively applied to gene discovery. The book shows how to successfully design, execute, and interpret preclinical and clinical molecular biological studies of stroke, work that will greatly advance its understanding, as well as rapid development of the next generation of stroke therapeutics.

From the reviews:

"The protocols presented in Stroke Genomics: Methods and Reviews will greatly benefit scientists interested in the molecular biology as well as the genetic and genomic basis of strokes." - Journal of Chemical Neuroanatomy

"...very interesting and informative...an attractive and interesting overview of the different aspects of the current stroke research...can be recommended as a source of useful and up-to-date practical and theoretical information on stroke genetics and on stroke associated gene expression." - European Neurology

"This book gives the opportunity for experts in the field to explore the practical and experimental applications of genomic and molecular biology research to the treatment of stroke. ... The book also indicates detailed methods for studying the molecular biology of stroke. ... It can be recommended if one is interested in the basic scientific background that underlies central nervous system pathology ... ." (J. V. Byrne, Neuroradiology, Vol. 47, 2005)

Prefacep. v
Contributorsp. ix
Introduction to Stroke Genomicsp. 3
Preclinical Models and Gene Manipulation
Choice, Methodology, and Characterization of Focal Ischemic Stroke Models: The Search for Clinical Relevancep. 19
Mutant Animal Models of Stroke and Gene Expression: The Stroke-Prone Spontaneously Hypertensive Ratp. 49
Gene Therapy in Neurological Diseasep. 75
Stem Cell Transplantation After Middle Cerebral Artery Occlusionp. 89
Endogenous Brain Protection: Models, Gene Expression, and Mechanismsp. 105
Production of Transgenic and Mutant Mouse Modelsp. 185
3-Nitroproprionic Acid Model of Metabolic Stress: Assessment by Magnetic Resonance Imagingp. 203
Clinical Paradigms
Practicalities of Genetic Studies in Human Strokep. 223
Evaluation of the Interactions of Common Genetic Mutations in Strokep. 241
Assessing Differential Expression
Technologies of Disease-Related Gene Discovery Using Preclinical Models of Strokep. 253
Quantitative Analysis of Gene Transcription in Stroke Models Using Real-Time RT-PCRp. 265
Effective Analysis of Genomic Datap. 285
Bioinformatic Approaches to Assigning Protein Function From Novel Sequence Datap. 313
Pragmatic Target Discovery From Novel Gene to Functionally Defined Drug Target: The Interleukin-1 Storyp. 333
Indexp. 347
Table of Contents provided by Rittenhouse. All Rights Reserved.

ISBN: 9781588293336
ISBN-10: 1588293335
Series: Methods in Molecular Medicine
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 351
Published: 21st September 2004
Publisher: Humana Press Inc.
Country of Publication: US
Dimensions (cm): 23.5 x 15.5  x 1.91
Weight (kg): 0.77