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Standardization of Epidemiologic Studies of Host Susceptibility : NATO Challenges of Modern Society - Janice S. Dorman

Standardization of Epidemiologic Studies of Host Susceptibility

NATO Challenges of Modern Society

By: Janice S. Dorman (Editor)

Hardcover Published: 31st January 1995
ISBN: 9780306448928
Number Of Pages: 285

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The incidence of insulin-dependent diabetes mellitus (100M) varies dramatically across racial groups and countries, with annual age-adjusted rates of approximately 40/100,000 per year in Finland, but only 0.51100,000 per year in China. Although reasons for these marked geographic differences are unknown, it is likely that genetic variations across populations play a m~or role. To determine the contribution of genetic factors to the global patterns of 100M incidence, international comparative studies are now being undertaken as part of the WHO Multinational Project for Childhood Oiabetes, known as the DIAMOND Project. It is, therefore, necessary to develop and implement epidemiologic standards for these investigations which can be applied across populations. This will ensure that comparable data are obtained in all countries, and that relevant scientific questions can be properly addressed. The development of standards for molecular epidemiologic studies of 100M is the of the NATO Advanced Research Workshop. During this meeting at the objective University of Pittsburgh, scientists from across the world convened to discuss issues relating to the standardization of: 1. the collection of family history data to assess the risk of 100M in first degree relatives, 2. case-control molecular epidemiology studies of 100M susceptibility, 3. HLA family studies, 4. laboratory methods and ONA technology transfer for genetic marker evaluations.

Preventing Diabetes - A Health Paradigm for the Next Century: Perspectives from the International Diabetes Federation (IDF)p. 1
The Contribution of DIAMOND and Multinational Studies to Epidemiological Researchp. 3
Beyond Insulin-dependent Diabetes Mellitus Registries: Capture-Recapture Approaches for Monitoring Incidencep. 7
Epidemiology of IDDM in Childhood in the Baltic Sea Regionp. 13
Standards for IDDM Epidemiology in Asiap. 27
Standards for Family History Data Collection and Analyses for the WHO DIAMOND Projectp. 35
Siberian IDDM Register and the Collection of Standardized Family History Informationp. 43
The Epidemiology of Familial Insulin-dependent Diabetes Mellitus (IDDM) in Hungaryp. 47
The IDDM Registry in the Province of Turin (Italy): Preliminary Data of the Familial Studyp. 53
The Risk of Insulin-dependent Diabetes in Offspring of Parents with Insulin-dependent Diabetesp. 57
Differential HLA Contribution from Fathers Versus Mothers to IDDM Susceptibilityp. 69
HLA-DR3 and DR4 Allele Segregation in IDDM Families and in Controlsp. 77
Preliminary Results of HLA Serological Typing of Insulin-dependent Diabetes Mellitus Families in Puerto Ricop. 83
Case-Control Molecular Epidemiology Studies: Standards for the WHO DIAMOND Projectp. 89
Genetic Determinants of IDDM Incidence: An International Study of HLA Haplotypes in Multiplex Parent-Child Familiesp. 101
Challenges in the Genetic Epidemiology of Insulin-dependent Diabetes Mellitusp. 111
Molecular Studies of Genetic Distance and Admixturep. 117
Immune Markers in Population Surveys and Family Studiesp. 125
Geographic Differences in Antibodies to Glutamic Acid Decarboxylase in Insulin-dependent Diabetes Mellitusp. 135
Does Beta Cell Death Result Exclusively From Genetically-Mediated Autoimmune Mechanisms? A Polemic - The Case for Environmental Factors in the Etiology of Insulin-dependent Diabetes Mellitusp. 145
IDDM Epidemiology in Russia: Current and Future Directionsp. 165
HLA-DQB1, DQA1 and DPB1 Alleles in Sardinian Patients with Insulin-dependent Diabetes Mellitusp. 173
Analysis of HLA-DQ Alpha and DQ Beta Genes in Type I (Insulin-dependent) Diabetesp. 181
The Incidence of IDDM and Molecular HLA-DQB1 Typing in Macedonian Childrenp. 193
HLA-DR, DQ System and IDDM in Japanesep. 193
Immunogenetic Aspects of Adult Onset IDDM in Koreap. 201
Predisposition to Insulin-dependent Diabetes Mellitus: Role of HLA and non-HLA Genesp. 209
Evidence for the "Genetic Admixture Hypothesis" That the Increased Incidence of IDDM Among African Americans Compared to Africans is Due in Large Part to Susceptibility Gene(s) Which Entered Through Admixture with the European American Gene Poolp. 217
HLA Studies Among North Indian Type I Diabetesp. 225
Advancements in DNA Technology as Applied to the Study of the Human Histocompatibility Complexp. 231
Molecular Epidemiology and DNA Technology Transfer: A Program for Developing Countriesp. 241
Effective DNA Technology Transfer to Developing Countriesp. 257
International Research and Training Through the Fogarty International Centerp. 265
Incidence, Seasonal Patterns and Clinical Characteristics of IDDM in the "Three Cities Study" in Poland for the Years 1986-1990p. 271
High Incidence of Insulin-dependent Diabetes Mellitus Among African American and Hispanic Children in Chicagop. 279
Indexp. 285
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780306448928
ISBN-10: 0306448920
Series: NATO Challenges of Modern Society
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 285
Published: 31st January 1995
Publisher: Springer Science+Business Media
Country of Publication: US
Dimensions (cm): 23.06 x 17.58  x 2.26
Weight (kg): 0.57

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