The term Spondylarthitides refers to a group of common rheumatic disorders affecting the spine and peripheral joints. The distribution of this disease is world-wide, with both men and women affected (the average age of onset being below 30 years). These also serve as a model system for understanding the interaction between disease-inducing micro-organisms, and genetically-susceptible host, since both of these components are particularly well defined in the spondylarthopathies. They are therefore of great interest from the point of veiw of understanding the pathogenesis of inflammatory and autoimune diseases, such as arthritis, inflammatory bowel disease, and insulin dependent diabetes mellitus, all of which involve an interplay of microbial and genetic factors. The Spondylarthritides provides up to date, in depth reviews of the current state of knowledge of the genetic, epidemiologic, microbiologic, and immunologic aspects of these disorders.
The book provides extensive clinical descriptions of the spondylarthritides, as well as reviews of the clinical features of these diseases. Written by an international team comprised of leading authorities in the field, the book will be of considerable interest to researchers and clinicians investigating these specific disorders, as well as related inflammatory disorders.
`A comprehensive up-to-date review by an internationally recognized group of clinicians and investigators...The layout of the book is well-balanced and both the clinical aspects and the basic research are well reviewed...Overall, this book is highly recommended for clinicians, both the rheumatologists and the non-rheumatologists, as well as the immunogeneticists and other research scientists interested in spondyloarthritides.'
Ruben Burgos-Vargas, Research Division, Hospital General de Mexico, Universidad Nacional Autonoma de Mexico.
`These relatively unconnected and partially overlapping chapters are clearly written but cover simple ground. They will help interested students, junior doctors or primary care physicians and may give trainee and experienced rheumatologists a chance to catch up on recent ideas about pathogenesis.'
Rheumatology in Europe, Vol.27/2, 1998
Terminology introduction, diagnostic criteria and overview
A worldwide overview: The epidemiology of HLA-B27 and associated spondylarthritides
Reative arthritis and Reiter's syndrome - the clinical spectrum
Enteric infections and arthritis: Clinical aspects
Psoriatic arthritis and spondylitis: A clinical approach
The eye in spondylarthritis
Enteric infections and arthritis: Bacteriological aspects
HLA-B27, ankylosing spondylitis, an the spondyloarthropathies
Mechanisms of arthritis associatied with chronic intestinal inflammations
Animal models of the spondyloarthropathies
Disease and outcome indices/instruments for the spondyloarthropathies
Ankylosing spondyltis - the patients point of view
HLA-B27 subtypes, disease susceptability and peptide binding specificity