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Solubility and Solubilization in Aqueous Media : American Chemical Society Publication - Samuel H. Yalkowsky

Solubility and Solubilization in Aqueous Media

American Chemical Society Publication

Hardcover Published: 18th November 1999
ISBN: 9780841235762
Number Of Pages: 480

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This book aims to provide the reader with a working knowledge of the various means of controlling the solubility or dissolution rate of a drug or other solute in an aqueous medium. The book begins with the factors which govern solubility in general and then looks at aqueous solubility in particular, including the properties of liquid mixtures and the thermodynamics of solutions formed from mixing two components. The bulk of the book is then devoted to techniques for altering solubility and dissolution rate of organic compounds in aqueous media. It discusses in detail the most commonly used solubility enhancers: buffers, cosolvents, surfactants, and complexants. Each chapter is self-contained and emphasizes the details for applying the techniques.

"Provides a working knowledge of the various means of controlling the solubility and dissolution rates of drugs and other biologically active compounds. Begins by describing factors that govern solubility in general and aqueous solubility in particular, then outlines various techniques for altering solubility and dissolution rates of organic compounds. Covers most commonly used solubility enhancers, such as buffers, cosolvents, surfactants, and complexants. A conceptual basis for understanding the degree of solubilization of a solute is provided for each technique, along with examples using a number of real drugs. For new and experienced researchers in pharmaceuticals. The author is professor of pharmaceutical sciences at the University of Arizona."--SciTech Book News "Provides a working knowledge of the various means of controlling the solubility and dissolution rates of drugs and other biologically active compounds. Begins by describing factors that govern solubility in general and aqueous solubility in particular, then outlines various techniques for altering solubility and dissolution rates of organic compounds. Covers most commonly used solubility enhancers, such as buffers, cosolvents, surfactants, and complexants. A conceptual basis for understanding the degree of solubilization of a solute is provided for each technique, along with examples using a number of real drugs. For new and experienced researchers in pharmaceuticals. The author is professor of pharmaceutical sciences at the University of Arizona."--SciTech Book News "Provides a working knowledge of the various means of controlling the solubility and dissolution rates of drugs and other biologically active compounds. Begins by describing factors that govern solubility in general and aqueous solubility in particular, then outlines various techniques for altering solubility and dissolution rates of organic compounds. Covers most commonly used solubility enhancers, such as buffers, cosolvents, surfactants, and complexants. A conceptual basis for understanding the degree of solubilization of a solute is provided for each technique, along with examples using a number of real drugs. For new and experienced researchers in pharmaceuticals. The author is professor of pharmaceutical sciences at the University of Arizona."--SciTech Book News "Provides a working knowledge of the various means of controlling the solubility and dissolution rates of drugs and other biologically active compounds. Begins by describing factors that govern solubility in general and aqueous solubility in particular, then outlines various techniques for altering solubility and dissolution rates of organic compounds. Covers most commonly used solubility enhancers, such as buffers, cosolvents, surfactants, and complexants. A conceptual basis for understanding the degree of solubilization of a solute is provided for each technique, along with examples using a number of real drugs. For new and experienced researchers in pharmaceuticals. The author is professor of pharmaceutical sciences at the University of Arizona."--SciTech Book News "Provides a working knowledge of the various means of controlling the solubility and dissolution rates of drugs and other biologically active compounds. Begins by describing factors that govern solubility in general and aqueous solubility in particular, then outlines various techniques for altering solubility and dissolution rates of organic compounds. Covers most commonly used solubility enhancers, such as buffers, cosolvents, surfactants, and complexants. A conceptual basis for understanding the degree of solubilization of a solute is provided for each technique, along with examples using a number of real drugs. For new and experienced researchers in pharmaceuticals. The author is professor of pharmaceutical sciences at the University of Arizona."--SciTech Book News

Mixing and Properties of Mixtures
Characterization of Solutions
Solubility and Partial Miscibility
Physical Modification of the Solute
Solubilization by pH Control
Solubilization by Cosolvents
Solubilization by Surfactants
Solubilization by Complexation
Effect of Cosolutes on Solubility
Overview and Strategy for Solubilization
Index
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780841235762
ISBN-10: 0841235767
Series: American Chemical Society Publication
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 480
Published: 18th November 1999
Publisher: AMER CHEMICAL SOC
Country of Publication: US
Dimensions (cm): 22.86 x 15.24  x 3.18
Weight (kg): 0.88

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