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Silica and Silica-Induced Lung Diseases - Vincent Castranova

Silica and Silica-Induced Lung Diseases

Hardcover Published: 20th December 1995
ISBN: 9780849347092
Number Of Pages: 432

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This book represents a comprehensive review of current concepts concerning the development, progression, and treatment of silica-induced lung diseases. The text begins with a complete review of the historical evolution of our understanding of silicosis and a discussion of the clinical and pathological features of this disease. It presents critical questions that must be resolved and then details state-of-the-art experiments that address these problems. The book presents an extensive discussion of new technologies that have increased our understanding of the relationship of surface properties of particulates to their cytotoxicity and pathogenicity. It also presents data that explain the intracellular and intercellular mechanisms involved in the pulmonary response to silica exposure.

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Pathogenic Considerations Regarding Disease Related to Silica Dust Exposurep. 3
History of Silicosisp. 7
Guidelines and Limits for Occupational Exposure to Crystalline Silicap. 15
Clinical Features of Silicosisp. 23
Pathologic Responses to Inhaled Silicap. 39
The Structure of Crystalline SiO[subscript 2]p. 63
The Structure of Silica Surfaces in Relation to Cytotoxicityp. 79
Role of Surface Free Radicals in the Pathogenicity of Silicosisp. 91
Surface Properties of Silica in Mixed Dustsp. 107
Questions and Controversies About the Pathogenesis of Silicosisp. 121
Potential Intracellular Messengers Involved in Silica Stimulation of Alveolar Macrophagesp. 137
Calcium-Mediated Silica Cytotoxicityp. 151
The Role of Interleukin-1 and Tumor Necrosis Factor [alpha] in the Lung's Response to Silicap. 163
Oxidant Release from Pulmonary Phagocytesp. 185
Lavagable Biomarkers of Exposure to Fibrogenic Dustsp. 197
Early Role of Lipid Inflammatory Mediators in Silica Toxicity: Possible Methods to Detoxify Silicap. 209
Acute Silicosis and the Activation of Alveolar Type II Cellsp. 229
Fibrogenic Factors: Identity and Mode of Releasep. 243
Immunological Aspects of Silicosisp. 253
Pulmonary Surfactant Adsorption and the Expression of Silica Toxicityp. 271
Suppressor of Silica-Induced Toxicity with Organosilane Surface Coatingp. 283
Suppression of the Cytotoxicity and Fibrogenicity of Silica with PVPNOp. 293
Modulation of Quartz Toxicity by Aluminump. 299
Bisbenzylisoquinoline Alkaloids: Animal Studiesp. 305
Bisbenzylisoquinoline Alkaloids: Experience from Chinap. 323
Pharmaceutical Considerations in the Use of Tetrandrine to Treat Silicosisp. 331
Carcinogenesis by Crystalline Silica: Animal, Cellular, and Molecular Studiesp. 345
Silica and Lung Cancerp. 383
Potential Mechanisms of Silica-Induced Cancerp. 397
Indexp. 407
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780849347092
ISBN-10: 0849347092
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 432
Published: 20th December 1995
Country of Publication: US
Dimensions (cm): 26.67 x 19.05  x 2.54
Weight (kg): 1.11
Edition Number: 1

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