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Signal Transduction and the Coordination of B Lymphocyte Development and Function I : Transduction of Bcr Signals from the Cell Membrane to the Nucleus - Louis B. Justement

Signal Transduction and the Coordination of B Lymphocyte Development and Function I

Transduction of Bcr Signals from the Cell Membrane to the Nucleus

Hardcover Published: 19th August 1999
ISBN: 9783540660026
Number Of Pages: 267

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Proper development and differentiation of B lymphocytes is es­ sential to ensure that an organism has the ability to mount an effective humoral immune response against foreign antigens. The immune system must maintain a balance between the deletion of harmful self-reactive B cells and the generation of a diverse rep­ ertoire of B cells that has the ability to recognize an almost un­ limited array of foreign antigens. The need to delete self-reactive cells is tempered by the need to avoid the generation of large functional holes in the repertoire of foreign antigen-specific B cells that patrol the periphery. To accomplish this, the immune system must reach a compromise by eliminating only the most dangerous autoreactive clones, while allowing less harmful au­ toreactive B cells to exist in the periphery where they may com­ plement the organism's ability to mount a rapid response against invading micro-organisms. Those autoreactive cells that do enter the peripheral pool are subject to a number of conditional re­ straints that effectively attenuate their ability to respond to self­ antigens. Deleterious alterations in the homeostasis between tolerance induction and recruitment of B cells into the functional repertoire may lead to increased susceptibility to autoimmune disease or infection, respectively. Therefore, delineation of the molecular processes that maintain immunological homeostasis in the B cell compartment is critical.

Signal Transduction via the B-cell Antigen Receptor: The Role of Protein Tyrosine Kinases and Protein Tyrosine Phosphatasesp. 1
The B-Cell Antigen Receptor: Formation of Signaling Complexes and the Function of Adaptor Proteinsp. 53
Intermediary Signaling EÇectors Coupling the B-Cell Receptor to the Nucleusp. 77
Involvement of the Lymphocyte Cytoskeleton in Antigen-Receptor Signalingp. 135
Pax-5/BSAP: Regulator of Speci(r)c Gene Expression and DiÇerentiation in B Lymphocytesp. 169
Receptor Modulators of B-Cell Receptor Signalling ± CD19/CD22p. 195
Positive and Negative Signaling in B Lymphocytesp. 213
Subject Indexp. 261
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9783540660026
ISBN-10: 354066002X
Series: Current Topics in Microbiology and Immmunology
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 267
Published: 19th August 1999
Publisher: SPRINGER VERLAG GMBH
Country of Publication: DE
Dimensions (cm): 23.39 x 15.6  x 1.75
Weight (kg): 0.58

Earn 426 Qantas Points
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