This book uniquely relates the broad impact of signal transduction research on the understanding and treatment of human disease. There have been significant advances in the area of signaling in disease processes, yet no resource presently connects these advances with understanding of disease processes and applications for novel therapeutics. Given the emphasis on translational research and biological relevance in biotechnology, and, conversely, the importance of molecular approaches for clinical research, it is evident that a single resource bridging signaling research and human disease will be invaluable.
"The book is attractively laid out with clear, well-labeled figures and charts?" (Journal of Natural Products, March 2005)
"...the overall worth of the book is in the excellent job it does of taking readers from the etiology and management of the disease to our current understanding of the molecular mechanisms involved." (Quarterly Review of Biology, March-May 2005)
??a successful work?serves as a short summarising overview?? (Signal Transduction, No.1 ? 2, 2004)
"...appropriate for a textbook...pathways and their regulation are well explained and there are helpful tables and illustrations. The information is current and is well referenced...Finkel, Gutkind, and their coauthors have put together examples that illustrate the growing depth of understanding the roles of signal transduction in disease..." (Cell, January 9, 2004)
?...provides a sweeping look at current information derived from assessing the role of some kinases and phosphases on human conditions associated with disease...the book contains thoughtful, well-planned chapters...with extensive citations and excellent artwork...extremely valuable.? (Pharmaceutical Research, Vol. 20, No. 12, December 2003)
"[Signal Transduction and Human Disease] is the kind of monograph that can be read quickly to understand a critical area of basic biology... Very helpful in getting into the more complex literature."
?Myron L. Weisfeldt, M.D., Director, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland
"An excellent text. Well written, precise chapters that explain the interface between molecular medicine and clinical practice at a level appropriate for educated laypersons, physicians and scientists."
?Marschall S. Runge, M.D., Ph.D., Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina