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Sickle Cell Disease : Oxford Medical Publications - Graham R. Serjeant

Sickle Cell Disease

Oxford Medical Publications

Hardcover Published: 1st June 2001
ISBN: 9780192630360
Number Of Pages: 772

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Sickle cell disease was recognized to have a molecular basis more than 50 years ago, since when knowledge of the pathophysiology of the disease has paralleled the developments of molecular biology. Characterized by a striking red cell deformity, a great deal has been learnt about the mechanisms involved and animal models developed over the last 10 years have contributed to these studies. Despite greater understanding of the molecular mechanisms, this knowledge has had little impact in improving management at the bedside. It is the authors' belief that much of importance remains to be learnt from clinical studies which ultimately may define the questions most relevant for our molecular colleagues to answer. Jamaica has provided a superb setting for clinical studies, which initially documented the extremely variable clinical course and then proceeded to seek the determinants in a Cohort Study based on newborn diagnosis and follow-up which has continued for the past 27 years. This new edition of Sickle Cell Disease reviews the history and many of the recent developments in laboratory studies but retains the perspective of a practising clinician. A critical appraisal of the available observations and evidence has sought to define the best practice in its management.

" ... this remains an excellent overview of sickle cell disease. It is well written and easy to read ... I would consider this an excellent purchase for those with an interest in sickle cell disease." ACP News

Basic Concepts
Distribution of Sickle Cell Disease
Nomenclature and Genetics of Sickle Cell Disease
Diagnosis of Sickle Cell Disease
Pathophysiology of Sickle Cell Disease
Historical Aspects
The Bone Marrow
The Blood
The Liver
The Spleen
The Immune System
The Gut
Cardiovascular System
Pulmonary System
Leg Ulceration
Bone and Joint Lesions
The Painful Crisis
Renal Manifestations
The Nervous System
The Eyes
Physical and Sexual Development
Pregnancy and Contraception
Homozygous Sickle Cell Disease
Sickle Cell--Haemoglobin C Disease
Sickle Cell--Beta Thalassaemia
Other Forms of Sickle Cell Disease
Sickle Cell--Hereditary Persistence of Fetal Haemoglobin
The Sickle Cell Trait
Age and Patterns of Clinical Involvement
Causes of Mortalite
General Supportive Measures
Blood Transfusions
Therapeutic Attempts to Inhibit Sickling
Surgery and Anaesthesia
Screening and Sickle Cell Clinics
The Epidemiology of Sickle Cell Disease
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780192630360
ISBN-10: 0192630369
Series: Oxford Medical Publications
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 772
Published: 1st June 2001
Publisher: Oxford University Press
Country of Publication: GB
Dimensions (cm): 23.5 x 16.51  x 4.45
Weight (kg): 1.46
Edition Number: 3
Edition Type: Revised