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Self-Production of Supramolecular Structures : From Synthetic Structures to Models of Minimal Living Systems - G.R. Fleischaker

Self-Production of Supramolecular Structures

From Synthetic Structures to Models of Minimal Living Systems

By: G.R. Fleischaker (Editor), S. Colonna (Editor), Pier Luigi Luisi (Editor)

Hardcover Published: 31st October 1994
ISBN: 9780792331636
Number Of Pages: 317

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How did life begin on the Earth? The units of life are cells, which can be defined as bounded systems of molecules that capture energy and nutrients from the environment -- systems that expand, reproduce, and evolve over time, often into more complex systems. This book is the proceedings of a unique meeting, sponsored by NATO and held in Maratea, Italy, that brought together for the first time an international group of investigators who share an interest in how molecules self-assemble into supramolecular structures, and how those structures may have contributed to the origin of life.
The book is written at a moderately technical level, appropriate for use by researchers and by students in upper-level undergraduate and graduate courses in biochemistry and molecular biology. The overall interest of its subject matter provides an excellent introduction for students who wish to understand how the foundational knowledge of chemistry and physics can be applied to one of the most fundamental questions now facing the scientific community.
The editors are pioneers in defining what we mean by the living state, particularly the manner in which simple molecular systems can assume complex associations and functions, including the ability to reproduce. Each chapter of the book presents an up-to-date report of highly significant research. Two of the authors received medals from the National Academy of Science USA in 1994, and other research reported in the book has been featured in internationally recognized journals such Scientific American, Time, and Discover.

Introduction
Acknowledgments
Workshop Speakers
Historical overview to the quest of self-reproduction and artificial lifep. 3
On defining lifep. 23
A few precautionary words concerning terminologyp. 33
Molecular replication: From minimal to complex systemsp. 45
Self-replication and reproduction: From molecules to protocellsp. 65
Extrabiotic replication and self-assemblyp. 75
The prebiotic synthesis and replication of RNA oligomers: The transition from prebiotic molecules to the RNA worldp. 89
Template-directed synthesis of oligomers: Kinetic vs. thermodynamic controlp. 99
Chirality and the first self-replicating moleculesp. 107
Are peptides possible support for self-amplification of sequence information?p. 115
Minimonsters: Evolutionary by-products of in vitro RNA amplificationp. 127
Models for the autocatalytic replication of RNAp. 137
RNA species that multiply indefinitely with RNA polymerasep. 147
Chemical oscillations and non-linear chemical kineticsp. 157
The chemical implementation of autopoiesisp. 179
Molecular recognition in micellesp. 199
Self-reproducing vesiclesp. 209
Sources and syntheses of prebiotic amphiphilesp. 217
Ancient paralogous duplications and the search for Archean cellsp. 231
Self-replication of oligonucleotides in reverse micellesp. 249
Liposomes from lipidonucleotides and from lipidopeptidesp. 255
Dendritic luminescent and redox-active supermolecules made of transition metal complexesp. 261
Layer-by-layer adsorption: The solid/liquid-interface as a template for the controlled growth of well-defined nanostructures of polyelectrolytes, proteins, DNA and polynucleotidesp. 267
Molecular recognition of amino acids by RNAp. 273
Towards nature's structural guidelines: Conclusions on the unsolved structures of RNA-dependent RNA polymerasesp. 279
A self-catalyzed (autopoietic) synthesis of an anionic surfactant: Experimental evidence and theoretical modelingp. 285
Competition, reciprocity, and mutation at the molecular level: Irradiation of a synthetic replicator generates a superior speciesp. 291
Giant vesiclesp. 295
Indexp. 303
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792331636
ISBN-10: 079233163X
Series: NATO Science Series C:
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 317
Published: 31st October 1994
Publisher: SPRINGER VERLAG GMBH
Country of Publication: NL
Dimensions (cm): 23.39 x 15.6  x 2.06
Weight (kg): 0.65

Earn 678 Qantas Points
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