Rodent Models of Neurodegenerative Disease

By: Pegah Javadpour (Editor), Rasoul Ghasemi (Editor)

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eText | 26 March 2026 | Edition Number 1

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Rodent Models of Neurodegenerative Disease explores neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, frontotemporal dementia, Lewy body disease, and prion disease which represent some of the most complex and devastating challenges in neuroscience. With rising prevalence in aging populations worldwide, these disorders place immense burdens on patients, families, and healthcare systems. This comprehensive volume, Rodent Models of Neurodegenerative Disease, provides an in-depth examination of the utility, strengths, and limitations of rodent models in unraveling the molecular, cellular, and behavioral aspects of neurodegeneration. Organized by disease, each chapter explores both genetic and non-genetic models, highlighting their relevance to human pathology, translational value, and contributions to therapeutic discovery.

Key features of this book include the following:

Detailed coverage of rodent models for major neurodegenerative diseases
Critical analysis of disease mechanisms, from protein aggregation and mitochondrial dysfunction to neuroinflammation and synaptic loss
A dedicated chapter on behavioral assays, bridging molecular pathology with motor, cognitive and social outcomes
Insights into the translational challenges of preclinical research and its role in shaping future therapies

With contributions from leading neuroscientists, this book serves as a valuable reference for researchers, graduate students, and professionals in neuroscience, neurology, pharmacology, and related fields. Whether for experimental design, model selection, or therapeutic evaluation, it provides an essential guide for advancing neurodegenerative disease research.