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Rho Gtpases : Molecular Biology Intelligence Unit - Mark H. Symons

Rho Gtpases

Molecular Biology Intelligence Unit

By: Mark H. Symons (Editor)

Hardcover Published: 31st May 2004
ISBN: 9780306479922
Number Of Pages: 236

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Members of the Rho family of small GTP-binding proteins (GTPases) are key signal transduction proteins that mediate signals initiated by growth factors, cytokines and cell adhesion proteins. Our knowledge about Rho GTPases has rapidly expanded over the past several years and Rho GTPases is the first book to provide a comprehensive overview of the regulation and functions of this important class of proteins.
This book includes several chapters dedicated to the review of various classes of proteins that control the localization and activation state of Rho GTPases. Additional chapters discuss the wide range of biological functions that are controlled by Rho GTPases, including the organization of the actin cytoskeleton, cell proliferation and cell motility.
Rho GTPases is essential reading for cell and molecular biologists, biochemists and geneticists. The critical roles of Rho family members in cancer and inflammatory diseases makes Rho GTPases also an invaluable guide for clinical investigators and pharmacologists.

Signalling networks of Rho GTPasesp. 1
Intracellular targeting of Rho family GTPases : implications of localization on functionp. 17
Regulation of the RhoGTPases by RhoGDIp. 32
Rho family guanine nucleotide exchange factorsp. 46
The superfamily of Rho GTPase-activating proteinsp. 68
Rnd proteins : intriguing members of the Rho familyp. 96
Rho GTPases in the organization of the actin cytoskeletonp. 107
Cell-cell adhesionp. 115
Ro GTPases and cell motilityp. 141
The RhoGTPase in tumor invasionp. 155
Rho family GTPases and cellular transformationp. 163
Rho GTPases in lipid metabolismp. 185
The role of Rho GTPases in vesicle traffickingp. 196
The dictyostelium Rho family of proteins and effectorsp. 208
Rho GTPases in plantsp. 219
Indexp. 231
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780306479922
ISBN-10: 0306479923
Series: Molecular Biology Intelligence Unit
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 236
Published: 31st May 2004
Publisher: Springer Science+Business Media
Country of Publication: US
Dimensions (cm): 23.67 x 15.8  x 2.13
Weight (kg): 0.59