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Review of Organic Functional Groups : Introduction to Medicinal Organic Chemistry - Lemke Roche Zito

Review of Organic Functional Groups

Introduction to Medicinal Organic Chemistry

Paperback Published: 13th January 2011
ISBN: 9781608310166
Number Of Pages: 208

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With its Student Workbook CD-ROM and new case studies, the Fifth Edition of this acclaimed self-paced review enables students to master the principles and applications of organic functional groups. Moreover, it prepares students for the required pharmacy courses in medicinal chemistry by thoroughly covering nomenclature, physical properties, chemical properties, and metabolism. As students progress through the text, they will develop such important skills as drawing chemical structures and predicting the solubility, instabilities, and metabolism of each organic functional group.

Prefacep. iii
Water Solubility and Chemical Bondingp. 1
Van der Waals Attraction (Forces)p. 2
Dipole-Dipole Bonding (Hydrogen Bond)p. 2
Ionic Attractionp. 3
Ion-Dipole Bondingp. 4
Alkanes (CnH2n+2p. 6
Alkenes (CnH2np. 11
Cycloalkanes: Alkene Isomersp. 13
Aromatic Hydrocarbonsp. 16
Haolgenated Hydrocarbonsp. 19
Case Studiesp. 21
Alcoholsp. 23
Case Studiesp. 27
Phenolsp. 29
Case Studiesp. 34
Ethers and Thioethersp. 36
Ethersp. 36
Thioethersp. 38
Case Studiesp. 40
Aldehydes and Ketonesp. 42
Case Studiesp. 47
Amines
Amines-Generalp. 49
Quaternary Ammonium Saltsp. 58
Case Studiesp. 59
Carboxylic Acidsp. 62
Case Studiesp. 70
Functional Derivatives of Carboxylic Acidsp. 73
Estersp. 73
Amidesp. 76
Carbonates, Carbamates, and Ureasp. 79
Amidines and Guanidinesp. 81
Case Studiesp. 82
Sulfonic Acids and Sulfonamidesp. 85
Sulfonic Acidsp. 85
Sulfonamidesp. 86
Case Studiesp. 87
Nitrogen Functional Groupsp. 90
Nitro Groupsp. 90
Nitrate Groupp. 90
Nitrite Groupp. 91
Oximesp. 92
Hydrazone/Hydrazine/Hydrazidep. 92
Case Studiesp. 93
Heterocyclesp. 96
Three-Membered Ring Heterocyclesp. 96
Four-Membered Ring Heterocyclesp. 99
Five-Membered Ring Heterocyclesp. 100
Five-Membered Ring Heterocycles with Two or More Heteroatomsp. 105
Six-Membered Ring Heterocyclesp. 112
Saturated Six-Membered Ring Heterocyclesp. 119
Seven- and Eight-Membered Ring Heterocyclesp. 120
Bicyclic Heterocycles: Five-Membered Ring Plus Six-Membered Ringp. 120
Bicyclic Heterocycles: Six-Membered Ring Plus Six-Membered Ringp. 125
Bicyclic Heterocycles: Six-Membered Ring Plus Seven-Membered Ringp. 128
Tricyclic Heterocyclesp. 129
Case Studiesp. 130
Oligonucleotides and Nucleic Acidsp. 133
Case Studiesp. 138
Proteinsp. 141
Case Studiesp. 151
Predicting Water Solubilityp. 153
The Role of Chemical Bonding between Dissimilar Organic Functional Groupsp. 153
Empiric Method for Predicting Water Solubilityp. 156
Analytic Method for Calculating Water Solubilityp. 160
Case Studiesp. 162
Stereoisomerism-Asymmetric Moleculesp. 164
Acidity and Basicityp. 167
Definitions of Acids and Basesp. 167
Relative Strengths of Acids and Basesp. 169
Reaction of an Acid with a Base in Waterp. 171
Acidic and Basic Organic Function Groupsp. 173
Drug Metabolismp. 176
Metabolic Enzymesp. 176
Learning Objectivesp. 184
Glossaryp. 187
Indexp. 189
Table of Contents provided by Ingram. All Rights Reserved.

ISBN: 9781608310166
ISBN-10: 1608310167
Audience: Professional
Format: Paperback
Language: English
Number Of Pages: 208
Published: 13th January 2011
Country of Publication: US
Dimensions (cm): 22.9 x 15.4  x 0.9
Weight (kg): 0.32
Edition Number: 5
Edition Type: Revised