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Retinoids : The Biochemical and Molecular Basis of Vitamin A and Retinoid Action :  The Biochemical and Molecular Basis of Vitamin A and Retinoid Action - Heinz Nau

Retinoids : The Biochemical and Molecular Basis of Vitamin A and Retinoid Action

The Biochemical and Molecular Basis of Vitamin A and Retinoid Action

By: Heinz Nau (Editor), William S. Blaner (Editor)

Hardcover Published: October 1999
ISBN: 9783540658924
Number Of Pages: 619

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This volume provides a state-of-the-art account of recent advances in the metabolism, actions and pharmacologic aspects of retinoid research and is the first comprehensive review in this rapidly moving research area. The chapters have a broad focus on the biologic uses and actions of retinoids and are written in a manner that will be useful both to readers with specialized research interests and those with only limited knowledge of this class of naturally occurring compounds and synthetic drugs Individual chapters deal with RAR and RXR specific agonists and antagonists, with retinoids in dermatology and oncology, with the physical properties of retinoids and how they affect retinoid actions, with retro-retinoic synthesis and functions, with the actions of retinoids in immunology and male reproduction.

Metabolism, Pharmocokinetics and Action of Retinoids
Physical-Chemical Properties and Action of Retinoidsp. 3
Biosynthesis, Absorption, Metabolism and Transport of Retinoidsp. 31
Retro-Retinoids: Metabolism and Actionp. 97
Retinoic Acid Synthesis and Metabolismp. 117
Binding Proteins and Nuclear Receptors
Nuclear Retinoid Receptors and Mechanisms of Actionp. 153
RAR-Selective Ligands: Receptor Subtype and Function Selectivityp. 185
RXR-Specific Agonists and Modulators: A New Retinoid Pharmacologyp. 215
Differentiation, Proliferation, and Cancer
Growth Control by Retinoids: Regulation of Cell Cycle Progression and Apoptosisp. 239
Retinoids and Differentiation of Normal and Malignant Hematopoietic Cellsp. 277
The Retinoids: Cancer Therapy and Prevention Mechanismsp. 301
Aberrant Expression and Function of Retinoid Receptors in Cancerp. 323
Development and Teratogenesis
Genetic and Molecular Approaches to Understanding the Role of Retinoids in Mammalian Spermatogenesisp. 347
The Role of Retinoids in Vertebrate Limb Morphogenesis: Integration of Retinoid- and Cytokine-Mediated Signal Transductionp. 369
Retinoids in Neural Developmentp. 399
Avian Embryo as Model for Retinoid Function in Early Developmentp. 443
Retinoid Receptors, Their Ligands, and Teratogenesis: Synergy and Specificity of Effectsp. 465
Skin
Vitamin A Homeostasis in Human Epidermis: Native Retinoid Composition and Metabolismp. 491
New Concepts for Delivery of Topical Retinoid Activity to Human Skinp. 521
Retinoid Receptor-Selective Agonists and Their Action in Skinp. 539
Special Effects
Retinoids in Mammalian Visionp. 563
Retinoids and Immunityp. 589
Subject Indexp. 611
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9783540658924
ISBN-10: 3540658920
Series: Handbook of Experimental Pharmacology
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 619
Published: October 1999
Publisher: SPRINGER VERLAG GMBH
Country of Publication: DE
Dimensions (cm): 23.39 x 15.6  x 3.51
Weight (kg): 1.08

Earn 1834 Qantas Points
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