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Restoring Function to the Injured Human Spinal Cord : Advances in Anatomy, Embryology and Cell Biology - K.J. Harrington

Restoring Function to the Injured Human Spinal Cord

Advances in Anatomy, Embryology and Cell Biology

By: Richard B. Borgens, K.J. Harrington (Illustrator)

Paperback

Published: 17th April 2003
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This book has two major themes: one, to provide a general un­ derstanding of the biology of spinal cord injury (SCI) in ani­ mal models and their relationship to naturally occurring inju­ ry in man, and secondly, to review novel means to induce functional recovery from spinal cord injury based on develop­ mental biophysics and physiology. These are new innovations in the treatment of SCI, born of disciplines that have not re­ ceived much attention from investigators interested in the re­ pair and regeneration of the Central Nervous System (CNS). They include development of 4-Aminopyridine for chronic SCI; oscillating electrical fields and polymer infusion for acute SCI. Biochemistry, neurotransplantation techniques, and phar­ macological approaches have long dominated this literature. Curiously though, it is these former techniques that are more practical and are rapidly moving into human clinical studies, or have already begun then. All of these clinical therapies have been developed at the Center for Paralysis Research at Purdue University, mirroring the backgrounds and interests of the electrophysiologists and biophysicists of our Research Center's faculty. Two of the three experimental therapies for SCI devel­ oped at Purdue University are now in human clinical trials, and a third will soon begin. They frame the emphasis of this text.

Foreword
A Brief Primer on Spinal Cord Injuryp. 1
The Behavioral Catastrophe is Rooted in Injury to White Matterp. 3
The Scar As a Barrier To Regenerationp. 19
Treating the Acute and Chronic Injury: Historical Perspectivep. 25
Concerning Behavioral Models for Spinal Cord Injury in Animalsp. 29
Axonal Regenerationp. 41
Treatment Possibilities of the New Biologyp. 51
Biologically Produced Electrical Fields: Physiology Spoken Herep. 67
Endogenous Voltages and the Reaction of the Neuron to Injuryp. 81
The Responses of Isolated Nerve Fibers in Culture to Applied DC Voltagesp. 83
Enhancing Spinal Cord Regeneration in situ with Applied Electric Fieldsp. 91
Recovery of the CTM Reflex in Spinal Injured Guinea Pigs after Exposure To Applied Extracellular Voltagesp. 105
From a Laboratory Tool To a Clinical Applicationp. 107
Naturally Occurring Spinal Injury in the Dog as a Model for Manp. 109
Sealing the Breach in Cell Membranes with Hydrophilic Polymersp. 119
Recovery of Behavioral and Physiological Function in vivop. 127
PEG Application in Clinical Cases of Canine Paraplegiap. 133
Conclusionp. 137
Referencesp. 141
Subject Indexp. 157
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9783540443674
ISBN-10: 3540443673
Series: Advances in Anatomy, Embryology and Cell Biology
Audience: Professional
Format: Paperback
Language: English
Number Of Pages: 161
Published: 17th April 2003
Publisher: Springer-Verlag Berlin and Heidelberg Gmbh & Co. Kg
Country of Publication: DE
Dimensions (cm): 23.5 x 15.5  x 1.27
Weight (kg): 0.38