This is an update of the molecular biology and clinical experience on the viruses which cause chronic hepatitis and liver carcinoma in humans and in model animals. Treatment of chronic hepatitis, reinfection after liver transplantation, in vitro replication of hepatitis B, C and D viruses, immunopathogenesis, variants of hepatitis viruses, oncogenicity, epidemiology and diagnosis and prevention are the major topics of the book. Thus, clinicians, laboratory physicians, molecular virologists and public health specialists may equally well profit from this book.
I. Replication of hepatitis viruses.- In vitro culture systems for hepatitis B and delta viruses.- Chronic infection in wood-chucks infected by a cloned hepatitis delta virus.- Detection of replicative intermediates of viral RNA in peripheral blood mononuclear cells from chronic hepatitis C virus carriers.- Susceptibility of human liver cell cultures to hepatitis C virus infection.- II. Molecular biology of hepatitis B virus.- Molecular basis of the diversity of hepatitis B virus core-gene products.- Characterization of the endogenous protein kinase activity of the hepatitis B virus.- The hepatitis B virus X gene product transactivates the HIV-LTR in vivo.- Accumulation of a cellular protein bearing c-myc-like antigenicity in hepatic and non-hepatic delta antigen expressing cells.- Duck hepatitis B virus infection, aflatoxin B1 and liver cancer in ducks.- III. Pathogenic and protective immune responses against hepatitis viruses.- Cell mediated immune response to hepatitis B virus nucleocapsid antigen.- Clinical and immunological aspects of hepatitis B virus infection in children receiving multidrug cancer chemotherapy.- Hepatitis C virus infection in type II essential mixed cryoglobulinemias.- Detection of hepatitis B virus DNA by polymerase chain reaction in vaccinated and non-vaccinated Senegalese children.- Duck hepatitis B virus (DHBV) as a model for understanding hepadnavirus neutralization.- IV. Variability of hepatitis B virus.- Implication of genetic variation on the pathogenesis of hepatitis B virus infection.- Hepatitis B virus C-gene variants.- Long-term response to interferon therapy in chronic hepatitis B: importance of hepatitis B virus heterogeneity.- Significance and relevance of serum preS1 antigen detection in wild-type and variant hepatitis B virus (HBV) infections.- Complete nucleotide sequences of six hepatitis B viral genomes encoding the surface antigen subtypes ayw4, adw4q?, and adrq? and their phylogenetic classification.- V. Diagnosis of chronic viral hepatitis.- Role of IgM antibody to hepatitis B core antigen in the diagnosis of hepatitis B exacerbations.- Serum IgM antibodies to hepatitis C virus in acute and chronic hepatitis C.- Isolate antibody to hepatitis C virus core antigen (C22) by RIB A 2: correlation with HCV-RNA and anti-NS5.- Is HCV transmitted by the vertical/perinatal route?.- VI. Clinical course and therapy of chronic viral hepatitis.- Multiple viral infections in HIV-infected children with chronically-evolving hepatitis.- Lymphoblastoid interferon in chronic hepatitis C patients that were "non responders" to recombinant interferon alpha (rIFN alpha).- Non responders to interferon therapy among chronic hepatitis patients infected with hepatitis C virus.- The relationship between LeY antigen and the therapeutic efficacy of interferon in chronic hepatitis C.- Antibodies to interferon alpha in patients.- VII. Liver transplantation and chronic viral hepatitis.- Patterns and mechanisms of hepatitis B/hepatitis D reinfection after liver transplantation.- Hepatitis C virus infection in liver allograft recipients.
Series: ACTA Mechanica
Number Of Pages: 304
Publisher: SPRINGER VERLAG GMBH
Country of Publication: AT
Dimensions (cm): 27.94 x 20.96
Weight (kg): 0.72