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Reproductive Toxicology : In Vitro Germ Cell Developmental Toxicology, from Science to Social and Industrial Demand - Jesus Del Mazo

Reproductive Toxicology

In Vitro Germ Cell Developmental Toxicology, from Science to Social and Industrial Demand

By: Jesus Del Mazo (Editor)

Hardcover

Published: 31st October 1998
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Numerous reports demonstrate that the reproductive system could be affected by multiple potential toxicological agents. The volume includes different aspects of the development of new approaches to in vitro testing using sperm cells and systems involved on reproduction in mammals. Comparative analysis of in vivo and in vitro methods has been included to take steps towards the further development of and applications of new systems for germline toxicology.

Advances in Improving Human Risk Estimation
Trends in male reproductive health. Environmental aspectsp. 1
Organochlorine compounds and xenoestrogens in human endometriump. 5
Assays to measure estrogen and androgen agonists and antagonistsp. 9
Development of a marker of estrogenic exposure in breast cancer patientsp. 29
New Approaches for in Vitro Analysis of Germ Cells Exposure to Toxicological Agents
In vitro culture systems for germ cells from mouse embryo: primordial germ cells and oocytesp. 41
Cell culture systems for the analysis of the male germinal differentiationp. 51
In vitro survival of human neoplastic germ cellsp. 59
Effects of rapamycin and fk 506 on rat sertoli cells in vitrop. 67
Flow cytometry as a tool for the evaluation of testicular toxicityp. 73
DNA damage in human and mouse spermatozoa after in vitro-irradiation assessed by the comet assayp. 79
In vitro models for the investigation of reproductive toxicology in the testisp. 95
Effect of metal compounds on boar sperm motility in vitrop. 105
In vitro analysis of xenoestrogens by enzyme linked receptor assays (ELRA)p. 113
Molecular and Developmental Approaches for Assessing Reproductive Toxicity
Current and future contributions of transgenic mice to the analysis of germline toxicologyp. 119
Evaluation of the placenta: suggestions for a greater role in developmental toxicologyp. 129
Protective mechanisms in germ cells: stress proteins in spermatogenesisp. 137
Molecular cloning and developmental pattern of expression of msj-1, a new male germ cell-specific DnaJ homologuep. 145
Analysis of gene regulation in Sertoli cells by a gene trap approachp. 153
Biochemical characterization of benomyl inhibition on endometrial growth during decidualization in ratsp. 163
Animal Risk Assessment. In Vivo / In Vitro Comparative Analysis
An overview of current in vivo test procedures to reproductive toxicologyp. 171
A new assay to assess aneuploidy in human-hamster embryosp. 185
Single day treatment - a feasible tool in revealing not dependent on maternal toxicity teratogenic potentialp. 191
The effect of parathion on mouse testicular and epididymal development cultured in chicken allantochorionp. 201
Evaluation of xenoestrogenic effects in fish on different organization levelsp. 207
Effects on female fertility and germinal cells in prepubertal and adult rats (Rattus norvegicus) after X-ray irradiationp. 215
Table of Contents provided by Syndetics. All Rights Reserved.

ISBN: 9780306460258
ISBN-10: 0306460254
Series: Advances in Experimental Medicine and Biology
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 223
Published: 31st October 1998
Publisher: Springer Science+Business Media
Country of Publication: US
Dimensions (cm): 23.5 x 15.5  x 1.91
Weight (kg): 1.15